MC3343
Based on 1 Customer Validation
MC3343, a DNMT inhibitor (EC50 of 5.7 μM) and a strong DNA binder, affects tumor proliferation by blocking OS cells in G1 or G2/M phases and induces osteoblastic differentiation through the specific re-expression of genes regulating this physiological process.
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- Pureté : 98.14%
- CAS No.: 1535187-91-7
- Formule: C27H23N7O
- Masse moléculaire:461.52
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Voir tous les produits spécifiques à Isoform DNA Methyltransferase
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | IC50 |
9.7 μM
Compound: 5
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Cytotoxicity against human MDA-MB-231 cells after 48 hrs by trypan blue exclusion assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by trypan blue exclusion assay
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[PMID: 24387159] |
| PBMC | IC50 |
57.4 μM
Compound: 5
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Cytotoxicity against human PBMC after 48 hrs by trypan blue exclusion assay
Cytotoxicity against human PBMC after 48 hrs by trypan blue exclusion assay
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[PMID: 24387159] |
| PC-3 | IC50 |
6.6 μM
Compound: 5
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Cytotoxicity against human PC3 cells after 48 hrs by trypan blue exclusion assay
Cytotoxicity against human PC3 cells after 48 hrs by trypan blue exclusion assay
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[PMID: 24387159] |
| Raji | IC50 |
8.8 μM
Compound: 5
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Cytotoxicity against human Raji cells after 48 hrs by trypan blue exclusion assay
Cytotoxicity against human Raji cells after 48 hrs by trypan blue exclusion assay
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[PMID: 24387159] |
| Sf9 | IC50 |
2.8 μM
Compound: 14
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Inhibition of His6-tagged human recombinant DNMT3a expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-biotinylated 45-bp unmethylated or hemimethylated oligonucleotide substrates and [3H]-AdoMet by liquid scinti
Inhibition of His6-tagged human recombinant DNMT3a expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-biotinylated 45-bp unmethylated or hemimethylated oligonucleotide substrates and [3H]-AdoMet by liquid scinti
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[PMID: 25406944] |
| Sf9 | IC50 |
9 μM
Compound: 14
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Inhibition of His6-tagged human recombinant DNMT1 expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-biotinylated 45-bp unmethylated or hemimethylated oligonucleotide substrates and [3H]-AdoMet by liquid scintil
Inhibition of His6-tagged human recombinant DNMT1 expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-biotinylated 45-bp unmethylated or hemimethylated oligonucleotide substrates and [3H]-AdoMet by liquid scintil
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[PMID: 25406944] |
| U-937 | IC50 |
4.3 μM
Compound: 5
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Cytotoxicity against human U937 cells after 48 hrs by trypan blue exclusion assay
Cytotoxicity against human U937 cells after 48 hrs by trypan blue exclusion assay
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[PMID: 24387159] |
Chemical Information
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CAS No. 1535187-91-7
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Appearance Solid
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Masse moléculaire 461.52
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Formule C27H23N7O
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Color White to light yellow
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SMILES
O=C(C1=CC(NC2=C3C=CC=CC3=NC=C2)=CC=C1)NC4=CC(NC5=NC(N)=NC(C)=C5)=CC=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : ≥ 100 mg/mL (216.68 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1668 mL | 10.8338 mL | 21.6675 mL | 54.1688 mL |
| 5 mM | 0.4334 mL | 2.1668 mL | 4.3335 mL | 10.8338 mL | |
| 10 mM | 0.2167 mL | 1.0834 mL | 2.1668 mL | 5.4169 mL | |
| 15 mM | 0.1445 mL | 0.7223 mL | 1.4445 mL | 3.6113 mL | |
| 20 mM | 0.1083 mL | 0.5417 mL | 1.0834 mL | 2.7084 mL | |
| 25 mM | 0.0867 mL | 0.4334 mL | 0.8667 mL | 2.1668 mL | |
| 30 mM | 0.0722 mL | 0.3611 mL | 0.7223 mL | 1.8056 mL | |
| 40 mM | 0.0542 mL | 0.2708 mL | 0.5417 mL | 1.3542 mL | |
| 50 mM | 0.0433 mL | 0.2167 mL | 0.4334 mL | 1.0834 mL | |
| 60 mM | 0.0361 mL | 0.1806 mL | 0.3611 mL | 0.9028 mL | |
| 80 mM | 0.0271 mL | 0.1354 mL | 0.2708 mL | 0.6771 mL | |
| 100 mM | 0.0217 mL | 0.1083 mL | 0.2167 mL | 0.5417 mL |
MC3343 Related Classifications
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