NF-115
NF-115 is a glycolipid and Neurostatin analog. NF-115 inhibits the expression of the ARHGDIA gene and alters the biosynthetic pathway of glycosphingolipids. NF-115 induces Apoptosis. NF-115 exhibits anticancer activity against glioma. NF-115 can be used in research related to glioma, glioblastoma and neuroectodermal tumors.
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- CAS No.: 368870-53-5
- Formule: C21H41NO9
- Masse moléculaire:451.56
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
NF-115 (43 µM) inhibits the proliferation of human U-373 glioma cells (ID50 = 43 μM)[1].
NF-115 (180 μM) inhibits proliferation of U373-MG human astrocytoma cells with an ID50 of 180 μM[3].
NF-115 alters gene expression in U373-MG human glioblastoma cells, repressing 491 genes and up-regulating 76 genes, including specific repression of ARHGDIA, SLC4A2, YWHAE, TP53, and BCL2L1 with fold changes ranging from -0.3 to -0.7 relative to untreated controls[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human U373-MG and T98G astrocytoma cell lines
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Concentration:250–500 μM
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Incubation Time:24 h
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Result:Inhibited the proliferation of U373-MG and T98G astrocytoma cell lines.
NF-115 disrupts astrocytomas implanted in immunodeficient mice[2].
NF-115 disrupts neuroectodermal tumors implanted in rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:not specified strain[1]
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Dosage:NF-115 loaded on slow-delivery polymer disc
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Administration:intratumoural; daily; 15 days
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Result:Caused a progressive decrease in tumour volume until total disappearance in treated rats
Chemical Information
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CAS No. 368870-53-5
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Masse moléculaire 451.56
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Formule C21H41NO9
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SMILES
O(CCCCCCCC)[C@@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](COCC(CO)(CO)CO)O1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Nieto-Sampedro M, et al. Natural, synthetic and semisynthetic glycolipid inhibitors of glioma growth. Expert Opin Ther Pat. 2004;14(4):487-497. [Content Brief]
[2]. Nieto-Sampedro M, et al. Natural, synthetic and semisynthetic glycolipid inhibitors of glioma growth. Expert Opin Ther Pat. 2004 Apr;14(4):487-97. [Content Brief]
[3]. Doncel-Pérez E, et al. Synthetic glycolipids for glioma growth inhibition developed from neurostatin and NF115 compound. Bioorg Med Chem Lett. 2013 Jan 15;23(2):435-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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