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Cat. No.: HY-180370

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Nitromemantine

(Synonyms: NitroSynapsin; YQW-036; NMI-6979)

Nitromemantine (NitroSynapsin) is a nitrate derivative of Memantine (HY-B0591) and is a dual-functional NMDAR antagonist. Nitromemantine exhibits significant efficacy in rodent models of cerebral infarction through a dual mechanism of blocking channels and regulating receptors via NO/redox regulation. Nitromemantine can target ischemic neurons under hypoxic conditions and enhance its activity. Nitromemantine inhibits the current induced by NMDA, with its IC₅₀ being 2.4 μM. Nitromemantine can be used for the study of cerebral ischemic stroke.

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CAS No.: 765890-91-3
Formule: C₁₄H₂₄N₂O₃
Masse moléculaire:268.35

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Nitromemantine Chemical Structure

CAS No.: 765890-91-3

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Chemical Information

CAS No. 765890-91-3
Masse moléculaire 268.35
Formule C₁₄H₂₄N₂O₃
SMILES

CCC1(C2)CC3(CC)CC2(N)CC(C3)(O[N+]([O-])=O)C1
Synonyms

NitroSynapsin; YQW-036; NMI-6979
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Takahashi H, et al. Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease. Sci Rep. 2015 Oct 19;5:14781. [Content Brief]

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Nitromemantine

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Chemical Information

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Références

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Nitromemantine Related Classifications

HY-180370 Related Classifications