Pentosidine TFA
Pentosidine TFA is a fluorescent advanced glycation end product (AGE) and cross-linker. Pentosidine TFA is a fluorescent cross-linked structure formed by lysine and arginine in sugar oxidation reactions, and it is commonly found in collagen, skin, bone, lens and plasma proteins. Pentosidine TFA is used in research related to type 1 diabetes, brown cataracts, rheumatoid arthritis, atherosclerosis and neurodegenerative diseases.
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- CAS No.: 225784-09-8
- Formule: C19H27F3N6O6
- Masse moléculaire:492.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Pentosidine (equimolar pentoses; 6 days at 37 °C) TFA forms in young human dura mater collagen incubated with pentoses at 37 °C for 6 days, with ribose driving the most robust formation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 225784-09-8
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Masse moléculaire 492.45
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Formule C19H27F3N6O6
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SMILES
OC(C(F)(F)F)=O.OC([C@@H](N)CCCCN1C2=NC(NCCC[C@H](N)C(O)=O)=NC2=CC=C1)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Sell DR, et al. Pentosidine: a molecular marker for the cumulative damage to proteins in diabetes, aging, and uremia. Diabetes Metab Rev. 1991;7(4):239-251. [Content Brief]
[2]. Requena JR, et al. Measurement of pentosidine in biological samples. Methods Mol Med. 2000;38:209-217. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pentosidine TFA Related Classifications
HY-113033A Related Classifications
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