PU24FCl
PU24FCl is a specific inhibitor of Hsp90. PU24FCl exhibits wide-ranging anti-cancer activities. PU24FCl accumulates in tumors while being rapidly cleared from normal tissue.
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- CAS No.: 422508-46-1
- Formule: C20H21ClFN5O3
- Masse moléculaire:433.86
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
IC50 & Target
[1]|
HSP90 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | GI50 |
3.9 μM
Compound: 8
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Cellular activity against human colon tumor cell line, HCT116
Cellular activity against human colon tumor cell line, HCT116
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[PMID: 14698151] |
| MCF7 | IC50 |
1.2 μM
Compound: PUC24FCI
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Antiproliferative activity against human MCF7 cells by MTS assay
Antiproliferative activity against human MCF7 cells by MTS assay
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[PMID: 17488003] |
| MCF7 | IC50 |
1.7 μM
Compound: PUC24FCI
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Inhibition of human recombinant HSP90 in MCF7 cells assessed as Her2 degradation
Inhibition of human recombinant HSP90 in MCF7 cells assessed as Her2 degradation
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[PMID: 17488003] |
| MCF7 | IC50 |
2.5 μM
Compound: PUC24FCI
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Binding affinity to human recombinant HSP90 in MCF7 cell lysates assessed as inhibition of biotinylated-geldanamycin binding
Binding affinity to human recombinant HSP90 in MCF7 cell lysates assessed as inhibition of biotinylated-geldanamycin binding
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[PMID: 17488003] |
| MCF7 | IC50 |
7 μM
Compound: PUC24FCI
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Selectivity for HSP90 in MCF7 cells over HSP90 in NDF cells
Selectivity for HSP90 in MCF7 cells over HSP90 in NDF cells
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[PMID: 17488003] |
| MDA-MB-468 | EC50 |
0.23 μM
Compound: 4
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Effective concentration against heat shock protein HSP90-alpha in MDA-MB-468 cells
Effective concentration against heat shock protein HSP90-alpha in MDA-MB-468 cells
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[PMID: 15828828] |
| SK-BR-3 | IC50 |
0.66 μM
Compound: PU24FCl
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Displacement of GM-cy3B from Hsp90 in human SKBR3 cells after 24 hrs by fluorescence polarization assay
Displacement of GM-cy3B from Hsp90 in human SKBR3 cells after 24 hrs by fluorescence polarization assay
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[PMID: 24548207] |
| SK-BR-3 | IC50 |
1.8 μM
Compound: 4
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Inhibitory concentration against SKBr3 cell line
Inhibitory concentration against SKBr3 cell line
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[PMID: 15828828] |
| SK-BR-3 | IC50 |
2 μM
Compound: PU24FCl
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Inhibition of Hsp70 in human SKBR3 cells assessed as HER2 protein degradation by Western blotting analysis
Inhibition of Hsp70 in human SKBR3 cells assessed as HER2 protein degradation by Western blotting analysis
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[PMID: 24548207] |
| SK-BR-3 | IC50 |
2.5 μM
Compound: PU24FCl
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Inhibition of Hsp70 in human SKBR3 cells assessed as RAF1 protein degradation by Western blotting analysis
Inhibition of Hsp70 in human SKBR3 cells assessed as RAF1 protein degradation by Western blotting analysis
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[PMID: 24548207] |
| SK-BR-3 | IC50 |
2.9 μM
Compound: PU24FCl
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Growth inhibition of human SKBR3 cells after 72 hrs by Alamar Blue assay
Growth inhibition of human SKBR3 cells after 72 hrs by Alamar Blue assay
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[PMID: 24548207] |
Chemical Information
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CAS No. 422508-46-1
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Masse moléculaire 433.86
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Formule C20H21ClFN5O3
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SMILES
FC1=NC2=C(N=C(CC3=CC(OC)=C(C(OC)=C3Cl)OC)N2CCCC#C)C(N)=N1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PU24FCl Related Classifications
HY-11039 Related Classifications
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