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Cat. No.: HY-14334

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SAM-315

Name: SAM-315
Brand: MedChemExpress
SKU: HY-14334
Availability: PreOrder

(Synonyms: WAY-255315)

SAM-315 (WAY-255315) is a potent antagonist of 5-Hydroxytryptamine-6, with K_i and IC₅₀ of 1.1 nM and 4.6 nM, respectively. SAM-315 significantly increases acetylcholine and glutamate release in hippocampus of the brain.

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CAS No.: 744218-85-7
Formule: C₂₁H₂₀N₄O₂S
Masse moléculaire:392.47

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

SAM-315 Chemical Structure

CAS No.: 744218-85-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- Essai clinique
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target

5-HT₆ Receptor

4.6 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform 5-HT Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	13 nM Compound: 8at	Antagonist activity at human cloned 5HT6 receptor expressed in human HeLa cells by cyclase assay Antagonist activity at human cloned 5HT6 receptor expressed in human HeLa cells by cyclase assay	[PMID: 20932009]

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 744218-85-7
Masse moléculaire 392.47
Formule C₂₁H₂₀N₄O₂S
SMILES

O=S(C1=NNC2=C1C=C(N3CCNCC3)C=C2)(C4=CC=CC5=C4C=CC=C5)=O
Synonyms

WAY-255315
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. 5-Piperazinyl-3-sulfonylindazoles as Potent and Selective 5-Hydroxytryptamine-6 Antagonists J. Med. Chem., Article ASAP DOI: 10.1021/jm1007825 Publication Date (Web): October 8, 2010

[2]. Kevin G Liu, et al. 5-Piperazinyl-3-sulfonylindazoles as Potent and Selective 5-Hydroxytryptamine-6 Antagonists. J Med Chem. 2010 Nov 11;53(21):7639-46. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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