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Cat. No.: HY-150895

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SI-191

SI-191 is a STAT3 inhibitor and a target protein ligand. SI-191 inhibits the growth of cancer cells. SI-191 can be used in the research of acute leukemia and lymphoma. SI-191 can be used for the synthesis of PROTAC SD-91 (HY-150251).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2754428-37-8
Formule: C₄₀H₄₄N₇O₁₀P
Masse moléculaire:813.79

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SI-191 Chemical Structure

CAS No.: 2754428-37-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

STAT3

Voir tous les produits spécifiques à Isoform STAT :

Cellular Effect

Cell Line	Type	Value	Description	References
SU-DHL-1	IC₅₀	>10 μM Compound: SI-191	Antiproliferative activity against human SU-DHL-1 cells assessed as cell growth inhibition incubated for 4 days by CellTiter-Glo asssay Antiproliferative activity against human SU-DHL-1 cells assessed as cell growth inhibition incubated for 4 days by CellTiter-Glo asssay	[PMID: 34141084]

In Vitro

SI-191 (>10 μM) inhibits the growth of MOLM-16 acute leukemia cells, SU-DHL-1 lymphoma cells, and SUP-M2 lymphoma cells with IC₅₀ values greater than 10 μM for all three cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2754428-37-8
Masse moléculaire 813.79
Formule C₄₀H₄₄N₇O₁₀P
SMILES

CC(N1CC[C@H]2CC[C@H](N2C([C@H](C1)NC(C3=CC4=CC(C(P(O)(O)=O)=O)=CC=C4N3)=O)=O)C(N[C@H](C(NC(C5=CC=CC=C5)C6=CC=CC=C6)=O)CCC(N)=O)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Zhou H, et al. SD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression. ACS Med Chem Lett. 2021 May 10;12(6):996-1004. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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SI-191

Voir tous les produits spécifiques à Isoform STAT

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

SI-191 Related Classifications

HY-150895 Related Classifications