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Cat. No.: HY-P991717

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Sunakiment

(Synonyms: AZD-8630)

Sunakiment (AZD-8630) is a humanized IgG1λ monoclonal antibody inhibitor targeting thymic stromal lymphopoietin (TSLP), which enables direct airway delivery via a dry powder inhaler formulation. Sunakiment binds to TSLP and blocks its pro-inflammatory signal transduction. It is applicable to research on refractory asthma, asthma, and moderate-to-severe asthma.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2928519-36-0

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (256 KB)

Sunakiment Chemical Structure

CAS No.: 2928519-36-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Isotype
- Species Reactivity
- Essai clinique
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Isotype

immunoglobulin Fab VH-G1(CH1-7h)_L-lambda2

Species Reactivity

Human

Voir tous les produits spécifiques à Isoform Interleukin Related :

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

85480 [NCBI]

Accession

Q969D9-1

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Fab-G1_lambda

Application

ELISA, FACS, Functional assay

Chemical Information

CAS No. 2928519-36-0
SMILES

N/A
Synonyms

AZD-8630
Formulation

Please refer to the lot-specific COA for specific buffer information.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (256 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Références

[1]. Komori HK, et al. Potential of alarmin-targeted bispecific and combination therapies in airway disease. Frontiers in allergy. 2025;6:1700060. [Content Brief]

[2]. Doffman S, et al. Phase 1 Safety and Efficacy of AZD8630/AMG 104 Inhaled Anti‑TSLP in Healthy Volunteers and Patients With Asthma on Medium‑High Dose Inhaled Corticosteroid (ICS) and Long‑Acting Beta‑agonist (LABA) With Elevated Baseline Fractional Exhaled Nitric Oxide (FeNO) [abstract]. Am J Respir Crit Care Med. 2024;209(Suppl 1):A1386.

[3]. Doffman SR, et al. AZD8630/AMG 104, an inhaled anti-thymic stromal lymphopoietin antibody fragment, for moderate-to-severe asthma: Phase 1 randomized controlled trial. The Journal of allergy and clinical immunology. 2026 Apr 20. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- Isotype
- Species Reactivity
- Essai clinique
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

Sunakiment

Cytotoxicity LDH Assay Kit

DPBS Buffer (1×)

PBS Buffer (1×)

Voir tous les produits spécifiques à Isoform Interleukin Related