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Cat. No.: HY-135902

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Synucleozid

Name: Synucleozid
Brand: MedChemExpress
SKU: HY-135902
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(Synonyms: NSC 377363)

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

Synucleozid (NSC 377363) is a potent inhibitor of the SNCA mRNA that encodes α-synuclein protein. Synucleozid selectively targets the α-synuclein mRNA 5′ UTR at the designed IRE site, decreases the amount of SNCA mRNA loaded into polysomes and thereby inhibits SNCA translation. Synucleozid has the potential for the investigation of Parkinson’s disease.

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CAS No.: 502139-01-7
Formule: C₂₂H₂₀N₆
Masse moléculaire:368.43

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (280 KB)

Synucleozid Chemical Structure

CAS No.: 502139-01-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Publications (2)
Pureté et documentation
Références
Calculators
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Classifications
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Activité biologique

Description

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Cellular Effect

Cell Line	Type	Value	Description	References
CMK	IC₅₀	1.31 μM Compound: K313	Antiproliferative activity against human CMK cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay Antiproliferative activity against human CMK cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay	[PMID: 34046601]
HEL	IC₅₀	2.27 μM Compound: K313	Antiproliferative activity against human HEL cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay Antiproliferative activity against human HEL cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay	[PMID: 34046601]
K562	IC₅₀	1.08 μM Compound: K313	Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay	[PMID: 34046601]
MEG-01	IC₅₀	1.03 μM Compound: K313	Antiproliferative activity against human MEG-01 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay Antiproliferative activity against human MEG-01 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay	[PMID: 34046601]

In Vitro

Synucleozid (0.25-1 μM; 24 hours) abrogates cytotoxicity induced by α-synuclein preformed fibrils, which act as seeds and recruit endogenous α-synuclein to aggregate^[1].
Synucleozid (0-1 μM; 24 hours) binds to the A bulge near the base of the IRE hairpin, reduced levels of α-synuclein in a dose-dependent manner with an IC₅₀ of 500 nM, and inhibits α-synuclein protein expression in SH-SY5Y neuroblastoma cells^[1].
Synucleozid (100 nM-100 μM; 24 hours) binds to 2-AP-labeled and native IRE RNA with similar affinities. It decreases 2-AP emission with an EC₅₀ value of 2.7 ± 0.4 μM, recovery of 2-AP emissions is observed as a function of unlabeled SNCA IRE RNA (RNA-0) concentration, affording a competitive K_d of 1.5 ± 0.3 μM^[1].
Synucleozid (0.25-1 μM; 24 hours) decreases α-synuclein and other proteins that have IREs in their mRNA’s UTR including APP, PrP, Ferritin and TfR as a dose-dependent mannner. All panels is completed in SH-SY5Y cells, except for PrP protein which is assessed in Neuro-2A cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

SH-SY5Y neuroblastoma cells
Concentration:

0.25 μM, 0.5 μM, 1 μM
Incubation Time:

24 hours
Result:

Decreased LDH release as a dose-dependent manner.

Western Blot Analysis^[1]

Cell Line:

SH-SY5Y neuroblastoma cells
Concentration:

0.25 μM; 0.5 μM; 1 μM;
Incubation Time:

24 hours
Result:

Decreased α-synuclein expression as a concentration-dependent manner.

Chemical Information

CAS No. 502139-01-7
Masse moléculaire 368.43
Formule C₂₂H₂₀N₆
SMILES

N=C(C1=CC2=C(C=C1)C=C(C3=CC=C(NC4=CC=C(C(N)=N)C=C4)C=C3)N2)N
Synonyms

NSC 377363
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Cell Metab

Ferroplasticity drives social isolation-induced anxiety via a ventral hippocampal iron-α-synuclein axis. [Abstract]

2026 Jan 27:S1550-4131(25)00586-8. PMID: 41605214
Brain Behav Immun

Transfer of neuron-derived α-synuclein to astrocytes induces neuroinflammation and blood-brain barrier damage after methamphetamine exposure: Involving the regulation of nuclear receptor-associated protein 1. [Abstract]

2022 Nov:106:247-261. PMID: 36089218

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (280 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zhang P, et al. Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA.Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1457-1467. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Synucleozid

2 Cited Publications

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Activité biologique
- Description
- In Vitro
Chemical Information
Publications (2)
Pureté et documentation
Références

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Synucleozid

Publications Citing Use of MedChemExpress (MCE) Synucleozid

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis