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Cat. No.: HY-P991030

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Biologically Validated

Tabirafusp alfa

(Synonyms: OG-2072)

Avis client

Based on 1 Customer Validation

Tabirafusp alfa (OG-2072, KSI-101) is a bispecific antibody trap fusion protein that inhibits IL-6 and VEGF. Tabirafusp alfa is a first-in-class, high-strength intravitreal biologic designed to target IL-6 mediated inflammation and VEGF-mediated vascular permeability in macular edema secondary to inflammation (MESI).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté: 98.08%
CAS No.: 2839527-15-8

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Tabirafusp alfa Chemical Structure

CAS No.: 2839527-15-8

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Prix

Stock

Quantité

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
- Verified Bioactivity
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

IL-6^[1]

Voir tous les produits spécifiques à Isoform Interleukin Related :

In Vivo

Tabirafusp alfa (KSI-101) (10 mg/ocular/dose) administered via intravitreal injection (IVT) three times every 4 weeks was well-tolerated in cynomolgus monkeys, with no observed changes in body weight or effects on pathological or organ weight parameters^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gene ID

3569 [NCBI]

Accession

P05231

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

IgG1-kappa-[2PROTEINS]2-in-VH_1cys_drug

Application

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized IL-6 Protein, Human (HY-P7044) can bind Tabirafusp alfa. The EC₅₀ for this effect is 51.98 ng/mL.

Chemical Information

CAS No. 2839527-15-8
Appearance Liquid
Color Colorless to light yellow
SMILES

[Tabirafusp alfa]
Synonyms

OG-2072
Livraison

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (256 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Références

[1]. Yih-Shiou Hwang, et al. Bispecific trap-antibody inhibiting Interleukin-6 and Vascular Endothelial Growth Factor (KSI-101): Clinical PK/PD cohort in Asian patients with macular edema secondary to inflammation (MESI). ARVO Annual Meeting Abstract. June 2026.

[2]. John Sinclair, et al. Ocular Toxicity Study of KSI-101 Demonstrates Tolerability after Intravitreal Administration in Cynomolgus Monkeys. ARVO Annual Meeting Abstract. June 2025.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Activité biologique
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
- Biological Activity
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

Tabirafusp alfa

PBS Buffer (1×)

Cytotoxicity LDH Assay Kit

DPBS Buffer (1×)

Antibody Inhibitor Library

Voir tous les produits spécifiques à Isoform Interleukin Related

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Tabirafusp alfa Related Classifications

HY-P991030 Related Classifications