VT104
Based on 3 publication(s) in Google Scholar
VT104 is a potent and orally active YAP/TAZ inhibitor. VT104 prevents palmitoylation of endogenous TEAD1 and TEAD3 proteins. VT104 can be used in research of cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.94%
- CAS No.: 2417718-25-1
- Formule: C25H19F3N2O
- Masse moléculaire:420.43
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
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Publications Citing Use of MedChemExpress (MCE) VT104
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Customer Validation & Images
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Cell Proliferation/Viability Assay
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RT-PCR
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IP
Voir tous les produits spécifiques à Isoform YAP
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Activité biologique
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Cell Line
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Type | Value | Description | References |
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| NCI-H226 | IC50 |
0.042 μM
Compound: VT-104
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Cytotoxicity against human NCI-H226 cells assessed as cell viability at 10 uM measured for 7 days by celltiter-glo assay
Cytotoxicity against human NCI-H226 cells assessed as cell viability at 10 uM measured for 7 days by celltiter-glo assay
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[PMID: 35763499] |
VT104 (0-1000 nM) inhibits proliferation of NF2 mutant/defective cell line[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NCI-H226-tumor bearing mice[1]
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Dosage:0.3, 1, and 3 mg/kg
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Administration:Oral administration
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Result:Blocked NCI-H226 tumor growth in mice in dose-dependent manner.
Chemical Information
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CAS No. 2417718-25-1
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Appearance Solid
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Masse moléculaire 420.43
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Formule C25H19F3N2O
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Color White to off-white
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SMILES
O=C(C1=CC=C2C(C3=CC=C(C(F)(F)F)C=C3)=CC=CC2=C1)N[C@H](C4=NC=CC=C4)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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Mol Cell
2025 Sep 18;85(18):3425-3442.e10. PMID: 40914169 -
VT104 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Sep 1.
Dose response curves of VT104 (0.001-10 μM) in SCEACono2 (ONO2) cells examined in proliferation assay and clonogenic assay.
VT104 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Sep 1.
qPCR for YAP/TAZ-TEAD target genes upon treatment with VT104 (1 µM) for 24 hours in ONO2 cells in vitro (n=3).
VT104 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Sep 1.
YAP co-immunoprecipitation experiment in ONO2 cells treated with VT104 (1µM) for 24 hours.
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Solvant et solubilité
DMSO : 100 mg/mL (237.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Tang TT, et, al. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. Mol Cancer Ther. 2021 Jun;20(6):986-998. [Content Brief]
[2]. Barry ER, et, al. Recent Therapeutic Approaches to Modulate the Hippo Pathway in Oncology and Regenerative Medicine. Cells. 2021 Oct 11;10(10):2715. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3785 mL | 11.8926 mL | 23.7852 mL | 59.4629 mL |
| 5 mM | 0.4757 mL | 2.3785 mL | 4.7570 mL | 11.8926 mL | |
| 10 mM | 0.2379 mL | 1.1893 mL | 2.3785 mL | 5.9463 mL | |
| 15 mM | 0.1586 mL | 0.7928 mL | 1.5857 mL | 3.9642 mL | |
| 20 mM | 0.1189 mL | 0.5946 mL | 1.1893 mL | 2.9731 mL | |
| 25 mM | 0.0951 mL | 0.4757 mL | 0.9514 mL | 2.3785 mL | |
| 30 mM | 0.0793 mL | 0.3964 mL | 0.7928 mL | 1.9821 mL | |
| 40 mM | 0.0595 mL | 0.2973 mL | 0.5946 mL | 1.4866 mL | |
| 50 mM | 0.0476 mL | 0.2379 mL | 0.4757 mL | 1.1893 mL | |
| 60 mM | 0.0396 mL | 0.1982 mL | 0.3964 mL | 0.9910 mL | |
| 80 mM | 0.0297 mL | 0.1487 mL | 0.2973 mL | 0.7433 mL | |
| 100 mM | 0.0238 mL | 0.1189 mL | 0.2379 mL | 0.5946 mL |
VT104 Related Classifications
HY-134956 Related Classifications
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