Zorevunersen
Based on 1 Customer Validation
Zorevunersen is an antisense oligonucleotide targeting the Scn1a gene based on TANGO technology. Zorevunersen increases Scn1a mRNA transcripts and elevates the expression level of NaV1.1 protein. Zorevunersen restores the excitability of PV interneurons, thereby reducing seizures and prolonging survival in mice. Zorevunersen can be used for research on Dravet syndrome.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.50%
- CAS No.: 2415330-04-8
- Formule: C204H263N63O114P20S20
- Masse moléculaire:7197.20
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Stockage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Chemical Information
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MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:75% C57BL/6:25% 129S6/SvEvTac (Scn1a+/− Dravet Syndrome model)[1]
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Dosage:20 μg
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Administration:i.c.v.; single unilateral injection; postnatal day 2 (P2)
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Result:Completely prevented seizures in pre-weaning cohort.
Significantly reduced seizure frequency in post-weaning cohort.
Prolonged survival in post-weaning cohort.
Restored PV interneuron intrinsic excitability to vehicle-treated wild-type levels.
Significantly elevated action potential firing frequencies compared to vehicle-treated Scn1a+/− mice .
Failed to rescue reduced AP upstroke velocity of vehicle-treated Scn1a+/− PV interneurons.
Caused no significant difference in seizure frequency compared to vehicle-treated WT mice in wild-type cohort.
Significantly reduced PV interneuron excitability relative to vehicle-treated WT mice in wild-type cohort.
Chemical Information
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CAS No. 2415330-04-8
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Appearance Solid
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Masse moléculaire 7197.20
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Formule C204H263N63O114P20S20
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Color White to off-white
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SMILES
[Zorevunersen]
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Synonyms
STK-001
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Pureté et documentation
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Fiche technique (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2242 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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