Cot inhibitor-3
Cot inhibitor-3 (Compound 33) is a potent and selective cancer osaka thyroid (COT) kinase inhibitor, with an IC50 of 4 nM. Cot inhibitor-3 can be used to prevent inflammation-driven lameness.
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- CAS No.: 1984784-12-4
- Formule: C30H28N8O
- Masse moléculaire:516.60
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
IC50: 4 nM (cancer osaka thyroid)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf21 | IC50 |
0.004 μM
Compound: 33
|
Inhibition of human COT (66 to 395 residues) expressed in Sf21 cells using 5-Fluo-Ahx-AGAGSGQLIDSNleANSFVGTR-NH2 as substrate after 60 mins by caliper microfluidic mobility shift assay
Inhibition of human COT (66 to 395 residues) expressed in Sf21 cells using 5-Fluo-Ahx-AGAGSGQLIDSNleANSFVGTR-NH2 as substrate after 60 mins by caliper microfluidic mobility shift assay
|
[PMID: 27502541] |
Chemical Information
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CAS No. 1984784-12-4
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Masse moléculaire 516.60
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Formule C30H28N8O
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SMILES
C[C@H](CN1CCOCC1)NC2=NC3=C(C=C2)C=C(C=C3)N4C5=C(N=C4)C=NC6=CN=C(C7=CC=NC=C7)C=C56
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)