Crocin IV  (Synonyms: Dicrocin)

Crocin IV (Dicrocin), a crocetin glycoside, is a carotenoid pigment. Crocin IV has potent antioxidant activity^[1].

Crocin IV (Dicrocin; 10 μM; 24 hours) has little or no effect on the prolongation of cell survival in PC12 cell^[1].
Crocin IV enhances γ-GCS mRNA expression in serum-deprived and hypoxic PC12 cells^[1].
Measurements of cell viability, peroxidized membrane lipids and caspase-3 activity showed that the rank order of the neuroprotective potency at a concentration of 10 μM is crocin>tricrocin>dicrocin and picrocrocin (the latter two crocins had a little or no potency)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

652.68

C₃₂H₄₄O₁₄

57710-64-2

Solid

Brown to reddish brown

CC(/C=C/C=C(C)/C(O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)=O)=C\C=C\C=C(C)\C=C\C=C(C)\C(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)=O

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Takashi Ochiai, et al. Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo. Biochim Biophys Acta. 2007 Apr;1770(4):578-84.  [Content Brief]