1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. Daltroban

Daltroban (Synonyms: BM-13505; SKF 96148)

Cat. No.: HY-121018
Handling Instructions

Daltroban (BM-13505) is a selective and specific thromboxane A2 (TXA2) receptor antagonist. Daltroban increase intracellular calcium in vascular smooth muscle cells. Daltroban shows protective effect in reperfusion injury.

For research use only. We do not sell to patients.

Daltroban Chemical Structure

Daltroban Chemical Structure

CAS No. : 79094-20-5

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10 mM * 1 mL in DMSO USD 413 In-stock
Estimated Time of Arrival: December 31
5 mg USD 530 In-stock
Estimated Time of Arrival: December 31
10 mg USD 890 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Daltroban (BM-13505) is a selective and specific thromboxane A2 (TXA2) receptor antagonist. Daltroban increase intracellular calcium in vascular smooth muscle cells. Daltroban shows protective effect in reperfusion injury[1][2].

IC50 & Target

TXA2

 

In Vivo

Daltroban (BM-13505) (1 mg/kg; i.v.; per hour) exerts protective effect in reperfusion injury following acute myocardial ischemia in cats[2].
In comparison with vehicle (physiological saline)-treated cats, Daltroban (20 mg/kg per hour i.v.) reduces the ischaemia-induced rise in the ST segment and prevented the development of a Q-wave in the ECG during reperfusion. Daltroban protects the myocardium from ischaemic injury and that this effect involves prevention of ischaemia-induced leukocytosis[3].

Animal Model: Adult male cats (2.8 to 4.6 kg; anesthetized cat model)[2]
Dosage: 1 mg/kg
Administration: i.v.; 30 minutes before reperfusion at a rate of 1 mg/kg followed by 1 mg/kg/hour
Result: Significantly reduced the area of ischemic tissue as a percent of total left ventricular mass and total area at risk, without altering basic hemodynamics and thereby not influencing myocardial oxygen demand.
Molecular Weight

353.82

Formula

C₁₆H₁₆ClNO₄S

CAS No.

79094-20-5

SMILES

O=C(CC1=CC=C(C=C1)CCNS(=O)(C2=CC=C(C=C2)Cl)=O)O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DaltrobanBM-13505SKF 96148BM13505BM 13505SKF96148SKF-96148Prostaglandin ReceptorselectiveischaemicinjuryprotectivevascularsmoothmusclecellsInhibitorinhibitorinhibit

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Daltroban
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HY-121018
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