ddTTP tetrasodium 

ddTTP tetrasodium is a DNA polymerase γ inhibitor, with K_i values of 0.05 μM and 0.4 μM against bovine testicular DNA polymerase γ. ddTTP tetrasodium can be incorporated into DNA to cause termination of the extended DNA strand. ddTTP tetrasodium can be used in the research of HIV infection^[1].

ddTTP tetrasodium (0-100 μM; 30 min) potently inhibits bovine testicular DNA polymerase γ in a competitive manner relative to dTTP, with a K_i value of 0.05 μM when poly (rA)-oligo (dT) serves as the template-primer^[1].
Tetrasodium ddTTP (0-100 μM; 30 min) potently inhibits bovine testicular DNA polymerase γ in a competitive manner relative to dTTP, with a K_i value of 0.4 μM when activated calf thymus DNA is used as the template-primer^[1].
Tetrasodium ddTTP (2.5-10 μM; 60 min) can be incorporated into DNA by bovine testicular DNA polymerase γ and induce chain termination, and this effect is independent of 3'-exonuclease proofreading activity (verified by treatment with 1 mM 5'-GMP)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

554.10

C₁₀H₁₃N₂Na₄O₁₃P₃

O=[P](O[P](O[P](O[Na])(O[Na])=O)(O[Na])=O)(O[Na])OC[C@@H](O1)CC[C@@H]1N(C(NC2=O)=O)C=C2C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Izuta S, et al. The 5'-triphosphates of 3'-azido-3'-deoxythymidine and 2', 3'-dideoxynucleosides inhibit DNA polymerase gamma by different mechanisms. Biochem Biophys Res Commun. 1991 Sep 16;179(2):776-83.