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Art. -Nr.: HY-162575

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Anticancer agent 231

Anticancer agent 231 (Compound P5) is a tyrosine protein kinase inhibitor with a IC₅₀ value of 3.95 μM. Anticancer agent 231 inhibits the cell viability, cell proliferation, cell migration and cancer dryness of triple negative breast cancer (TNBC) cells by targeting EGFR-ERK 1/2 signaling pathway, and is expected to play an important role in the field of TNBC disease therapy.

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CAS. Nr.: 128519-30-2
Formel: C₂₃H₂₂ClN₃
Molecular Weight:375.89

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Anticancer agent 231 Chemical Structure

CAS. Nr.: 128519-30-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
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Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

ERK1

ERK2

Alle ERK Isoform-spezifische Produkte anzeigen :

In Vitro

Anticancer agent 231 (Compound P5) has good cytotoxicity and inhibits TNBC cells’ viability^[1].
Anticancer agent 231 (Compound P5) (1, 2, 4 μM, 14 days; 1, 2, 4 μM, 8 days) decreases the proliferation capacity of Hs578T cells and MDA MB-231 cells^[1].
Anticancer agent 231 (Compound P5) (1, 2, 4 μM, 12 h) decreases the migration ability of Hs578T cells^[1].
Anticancer agent 231 (Compound P5) (1, 2 μM) inhibits tumor stemness and enhances the sensitivity of TNBC cells to paclitaxel^[1].
Anticancer agent 231 (Compound P5) (1, 2, 4 μM; 5, 10, 20 μM) inhibits TNBC cells by targeting the EGFR-ERK 1/2 axis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Line:
Concentration:
Incubation Time:
Result:

Cell Viability Assay^[1].

Cell Line:

Hs578T cell, MDA MB 231 cell
Concentration:

0-40 μM
Incubation Time:

48 h
Result:

Exhibited the most cytotoxic effect against Hs578T cells and MDA MB 231 cells

Cell Proliferation Assay^[1].

Cell Line:

Hs578T cell
Concentration:

1, 2, 4 μM
Incubation Time:

14 days
Result:

Inhibited the colony formation of Hs578T cells

Cell Proliferation Assay^[1].

Cell Line:

MDA MB 231 cell
Concentration:

5, 10, 20 μM
Incubation Time:

8 days
Result:

Inhibited the colony formation of MDA MB 231 cells

Cell Migration Assay ^[1].

Cell Line:

Hs578T cell
Concentration:

1, 2, 4 μM
Incubation Time:

12 h
Result:

Inhibited the migration ability of Hs578T cells

Western Blot Analysis^[1].

Cell Line:

Hs578T cell, MDA MB 231 cell
Concentration:

1, 2, 4 μM; 5, 10, 20 μM
Incubation Time:

48 h
Result:

Reduced the EGFR expression level in Hs578T and MDA MB 231 cells and deactivated the EGFR in MDA MB 231 cells

Chemical Information

CAS. Nr. 128519-30-2
Molecular Weight 375.89
Formel C₂₃H₂₂ClN₃
SMILES

ClC1=CC=C(C2=NN(C3=CC=CC=C3)C(C4=CC=C(N(C)C)C=C4)C2)C=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Satriyo PB, et al. N-phenyl pyrazoline derivative inhibits cell aggressiveness and enhances paclitaxel sensitivity of triple negative breast cancer cells. Sci Rep. 2024 Jun 8;14(1):13200. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
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Anticancer agent 231

Alle ERK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Anticancer agent 231 Related Classifications

HY-162575 Related Classifications