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DL-Dithiothreitol

(Synonyms: DTT; rel-(2R,3R)-1,4-Dimercapto-2,3-butanediol)
45 Cited Publications
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Based on 45 publication(s) in Google Scholar

DL-Dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. When DL-Dithiothreitol is oxidized, it forms a stable six-membered ring with an internal disulfide bond.

For research use only. We do not sell to patients.

  • Purity: 98.31%
  • CAS No.: 3483-12-3
  • Formula: C4H10O2S2
  • Molecular Weight:154.25
  • Storage:

    4°C, protect from light, stored under nitrogen

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

  • DL-Dithiothreitol Chemical Structure
    DL-Dithiothreitol Chemical Structure
  • Experimental Validation Results for DL-Dithiothreitol
  • Experimental Validation Results for DL-Dithiothreitol
  • Experimental Validation Results for DL-Dithiothreitol
  • Experimental Validation Results for DL-Dithiothreitol
  • Experimental Validation Results for DL-Dithiothreitol
CAS No.: 3483-12-3
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Top Publications Citing

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Publications Citing Use of MedChemExpress (MCE) DL-Dithiothreitol

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  • DL-Dithiothreitol Chemical Structure
    DL-Dithiothreitol Chemical Structure
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    DL-Dithiothreitol purchased from MedChemExpress. Usage Cited in: Inflammation. 2025 Oct;48(5):3146-3155. [Abstract]

    Customer Validation
     The melanocytes were treated with TM (3 μM), thapsigargin (1 μM), or DTT (1 mM) for 24 h to induce ER stress. Increased expression of PERK, IRE1α, and CHOP.

  • 1/16

    DL-Dithiothreitol purchased from MedChemExpress. Usage Cited in: Inflammation. 2025 Oct;48(5):3146-3155. [Abstract]

    Customer Validation
     The melanocytes were treated with TM (3 μM), thapsigargin (1 μM), or DTT (1 mM) for 24 h to induce ER stress.

  • 1/16

    DL-Dithiothreitol purchased from MedChemExpress. Usage Cited in: Inflammation. 2025 Oct;48(5):3146-3155. [Abstract]

    Customer Validation
     The melanocytes were treated with TM (3 μM), thapsigargin (1 μM), or DTT (1 mM) for 24 h to induce ER stress. ER stress induced an increase in the apoptosis of melanocytes.

  • 1/16

    DL-Dithiothreitol purchased from MedChemExpress. Usage Cited in: Inflammation. 2025 Oct;48(5):3146-3155. [Abstract]

    Customer Validation
     Decreased Sirt1 protein levels in melanocytes after 24 h treatment with TM (3 μM), TG (1 μM), and DTT(1 mM).

  • 1/16

    DL-Dithiothreitol purchased from MedChemExpress. Usage Cited in: Vet Microbiol. 2020 Aug:247:108786. [Abstract]

    Customer Validation
     Vero cells were infected with PRV HB1201(0.1 MOI) for 12 h, followed by treatment with 0.5 mM AS for 30 min or 2 mM DTT for 1 h, respectively.

  • DL-Dithiothreitol