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Cat. No.: HY-117479

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CL67

CL67 is a potent hypoxia-inducible factor (HIF) pathway inhibitor. CL67 interferes G-quadruplex structures within promoter sequences. CL67 can be used in research of renal cancer.

For research use only. We do not sell to patients.

CAS No.: 1401242-86-1
Formula: C₃₈H₄₂N₁₀O₂
Molecular Weight:670.81

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

CL67 Chemical Structure

CAS No.: 1401242-86-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

CL67 is a potent hypoxia-inducible factor (HIF) pathway inhibitor. CL67 interferes G-quadruplex structures within promoter sequences. CL67 can be used in research of renal cancer^[1].

All HIF/HIF Prolyl-Hydroxylase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	IC₅₀	2.3 μM Compound: 13, CL67	Antiproliferative activity against human 786-O cells after 96 hrs by SRB assay Antiproliferative activity against human 786-O cells after 96 hrs by SRB assay	[PMID: 22889802]
A498	IC₅₀	2.5 μM Compound: 13, CL67	Antiproliferative activity against human A498 cells after 96 hrs by SRB assay Antiproliferative activity against human A498 cells after 96 hrs by SRB assay	[PMID: 22889802]
A549	IC₅₀	60 μM Compound: 13, CL67	Antiproliferative activity against human A549 cells after 96 hrs by SRB assay Antiproliferative activity against human A549 cells after 96 hrs by SRB assay	[PMID: 22889802]
HOS	IC₅₀	2.4 μM Compound: 13, CL67	Antiproliferative activity against human HOS cells after 96 hrs by SRB assay Antiproliferative activity against human HOS cells after 96 hrs by SRB assay	[PMID: 22889802]
HOS-TE85	IC₅₀	3.2 μM Compound: 13, CL67	Antiproliferative activity against human MNNG-HOS cells after 96 hrs by SRB assay Antiproliferative activity against human MNNG-HOS cells after 96 hrs by SRB assay	[PMID: 22889802]
HPAC	IC₅₀	7.3 μM Compound: 13, CL67	Antiproliferative activity against human HPAC cells after 96 hrs by SRB assay Antiproliferative activity against human HPAC cells after 96 hrs by SRB assay	[PMID: 22889802]
MCF7	IC₅₀	63 μM Compound: 13, CL67	Antiproliferative activity against human MCF7 cells after 96 hrs by SRB assay Antiproliferative activity against human MCF7 cells after 96 hrs by SRB assay	[PMID: 22889802]
MG-63	IC₅₀	7.9 μM Compound: 13, CL67	Antiproliferative activity against human MG63 cells after 96 hrs by SRB assay Antiproliferative activity against human MG63 cells after 96 hrs by SRB assay	[PMID: 22889802]
MIA PaCa-2	IC₅₀	16.8 μM Compound: 13, CL67	Antiproliferative activity against human MIAPaCa2 cells after 96 hrs by SRB assay Antiproliferative activity against human MIAPaCa2 cells after 96 hrs by SRB assay	[PMID: 22889802]
OST	IC₅₀	2.6 μM Compound: 13, CL67	Antiproliferative activity against human OST cells after 96 hrs by SRB assay Antiproliferative activity against human OST cells after 96 hrs by SRB assay	[PMID: 22889802]
PANC-1	IC₅₀	31 μM Compound: 13, CL67	Antiproliferative activity against human PANC1 cells after 96 hrs by SRB assay Antiproliferative activity against human PANC1 cells after 96 hrs by SRB assay	[PMID: 22889802]
PC-3	IC₅₀	8.05 μM Compound: 13, CL67	Antiproliferative activity against human PC3 cells after 96 hrs by SRB assay Antiproliferative activity against human PC3 cells after 96 hrs by SRB assay	[PMID: 22889802]
RCC4	IC₅₀	1.3 μM Compound: 13, CL67	Antiproliferative activity against human RCC4 cells after 96 hrs by SRB assay Antiproliferative activity against human RCC4 cells after 96 hrs by SRB assay	[PMID: 22889802]
RCC4/VHL	IC₅₀	2.6 μM Compound: 13, CL67	Antiproliferative activity against human RCC4/VHL cells after 96 hrs by SRB assay Antiproliferative activity against human RCC4/VHL cells after 96 hrs by SRB assay	[PMID: 22889802]
SAOS-2	IC₅₀	2.6 μM Compound: 13, CL67	Antiproliferative activity against human Saos2 cells after 96 hrs by SRB assay Antiproliferative activity against human Saos2 cells after 96 hrs by SRB assay	[PMID: 22889802]
TC-32	IC₅₀	0.9 μM Compound: 13, CL67	Antiproliferative activity against human TC32 cells after 96 hrs by SRB assay Antiproliferative activity against human TC32 cells after 96 hrs by SRB assay	[PMID: 22889802]
U2OS	IC₅₀	5.5 μM Compound: 13, CL67	Antiproliferative activity against human U2OS cells after 96 hrs by SRB assay Antiproliferative activity against human U2OS cells after 96 hrs by SRB assay	[PMID: 22889802]
WI-38	IC₅₀	91 μM Compound: 13, CL67	Cytotoxicity against human WI38 after 96 hrs by SRB assay Cytotoxicity against human WI38 after 96 hrs by SRB assay	[PMID: 22889802]

In Vitro

CL67 (RCC4 and RCC4VHL cells) inhibits HIF-1α protein in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1401242-86-1
Molecular Weight 670.81
Formula C₃₈H₄₂N₁₀O₂
SMILES

O=C(NC1=CC=CC(N2N=NC(C3=CC=C4C=CC(C5=CN(C6=CC(NC(CN(CC)CC)=O)=CC=C6)N=N5)=CC4=C3)=C2)=C1)CN(CC)CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sarah JW, et, al. CL67: A novel G-quadruplex stabilising agent inhibits the HIF-1 pathway. Cancer Res (2011) 71 (8_Supplement):4506.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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CL67

All HIF/HIF Prolyl-Hydroxylase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CL67 Related Classifications

HY-117479 Related Classifications