DU172
DU172 is a ligand for the adenosine A1 receptor (Adenosine A1 Receptor), with an IC50 of 24.9 nM against A1AR and an IC50 of 0.42 μM against A2AAR.
For research use only. We do not sell to patients.
- CAS No.: 321907-03-3
- Formula: C24H30FN5O5S
- Molecular Weight:519.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Adenosine Receptor Isoforms
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Biological Activity
DU172 (Compound 23a) potently binds to the A1 adenosine receptor on the cell membrane of DDT1 MF-2, with an IC50 of 24.9 nM for inhibiting [3H]DPCPX binding[2].
DU172 binds to the A2A adenosine receptor on the membrane of PC-12 cells, with an IC50 of 0.42 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 321907-03-3
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Molecular Weight 519.59
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Formula C24H30FN5O5S
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SMILES
O=C(NCCCN1C(=O)N(C(=O)C=2NC(=NC21)C3CCCCC3)CCC)C4=CC=C(C=C4)S(=O)(=O)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Glukhova A, et al. Structure of the Adenosine A1 Receptor Reveals the Basis for Subtype Selectivity. Cell. 2017;168(5):867-877.e13. [Content Brief]
[2]. Beauglehole AR, et al. Fluorosulfonyl-substituted xanthines as selective irreversible antagonists for the A(1)-adenosine receptor. J Med Chem. 2000;43(26):4973-4980. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DU172 Related Classifications
HY-165509 Related Classifications
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