Hydroflumethiazide
Based on 1 Customer Validation
Hydroflumethiazide (Methforylthiazidine) is an orally active and potent thiazide diuretic. Hydroflumethiazide possesses the ability to directly stimulate A cell secretion in the normal and alloxan diabetic pancreas.
For research use only. We do not sell to patients.
- Purity: 99.4%
- CAS No.: 135-09-1
- Formula: C8H8F3N3O4S2
- Molecular Weight:331.30
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Anti-diabetic Compound Library
HY-L040
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Endocrinology Compound Library
HY-L047
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Orally Active Compound Library
HY-L061
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FDA Approved & Pharmacopeial Drug Library
HY-L066
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Neuroprotective Compound Library
HY-L070
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Drug-Induced Liver Injury (DILI) Compound Library
HY-L076
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Sodium Channel Blocker Library
HY-L118
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Human Metabolite Library
HY-L123
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Withdrawn Drug Compound Library
HY-L140
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Off-patent Drug Library
HY-L141
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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Ion Channel Compound Library
HY-L166
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Multi-Target Compound Library
HY-L176
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Drug Repurposing Compound Library Plus
HY-L035P
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FDA-Approved Drug Library Plus
HY-L022P
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FDA-Approved Drug Library Mini
HY-L022M
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Mass Spectrometry Human Metabolite Library
HY-L215
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Nephrotoxicity Compound Library
HY-L229
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MCE Kinase Hinge Binder Fragment Library
HY-L907
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Membrane Transporter/Ion Channel Compound Library
HY-L011
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FDA-Approved Drug Library
HY-L022
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Drug Repurposing Compound Library
HY-L035
Biological Activity
Chemical Information
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CAS No. 135-09-1
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Appearance Solid
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Molecular Weight 331.30
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Formula C8H8F3N3O4S2
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Color White to off-white
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SMILES
O=S(C1=C(C(F)(F)F)C=C(C2=C1)NCNS2(=O)=O)(N)=O
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Synonyms
Methforylthiazidine; Rontyl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (377.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
[1]. Selvaag E, et al. Phototoxicity to sulphonamide derived oral antidiabetics and diuretics. Comparative in vitro and in vivo investigations. In Vivo. 1997 Jan-Feb;11(1):103-7. [Content Brief]
[2]. Brørs O, et al. Pharmacokinetics of a single oral dose of hydroflumethiazide in health and in cardiac failure.-. Eur J Clin Pharmacol. 1978 Nov 9;14(1):29-37. [Content Brief]
[3]. Hermansen K, et al. Effects of a thiazide diuretic (hydroflumethiazide) and a loop diuretic (bumetanide) on the endocrine pancreas: studies in vitro. Metabolism. 1985 Aug;34(8):784-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.0184 mL | 15.0922 mL | 30.1844 mL | 75.4610 mL |
| 5 mM | 0.6037 mL | 3.0184 mL | 6.0369 mL | 15.0922 mL | |
| 10 mM | 0.3018 mL | 1.5092 mL | 3.0184 mL | 7.5461 mL | |
| 15 mM | 0.2012 mL | 1.0061 mL | 2.0123 mL | 5.0307 mL | |
| 20 mM | 0.1509 mL | 0.7546 mL | 1.5092 mL | 3.7730 mL | |
| 25 mM | 0.1207 mL | 0.6037 mL | 1.2074 mL | 3.0184 mL | |
| 30 mM | 0.1006 mL | 0.5031 mL | 1.0061 mL | 2.5154 mL | |
| 40 mM | 0.0755 mL | 0.3773 mL | 0.7546 mL | 1.8865 mL | |
| 50 mM | 0.0604 mL | 0.3018 mL | 0.6037 mL | 1.5092 mL | |
| 60 mM | 0.0503 mL | 0.2515 mL | 0.5031 mL | 1.2577 mL | |
| 80 mM | 0.0377 mL | 0.1887 mL | 0.3773 mL | 0.9433 mL | |
| 100 mM | 0.0302 mL | 0.1509 mL | 0.3018 mL | 0.7546 mL |
Hydroflumethiazide Related Classifications
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