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Cat. No.: HY-135478

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LY393615

(Synonyms: NCC1048)

LY393615 (NCC1048) is a novel neuronal Ca²⁺ (calcium channel) and Na ⁺ channel (sodium channel) blocker with IC₅₀s of 1.9 μΜ and 5.2 μΜ for α1A and α1B calcium channel subunits. LY393615 has good brain penetration and neuroprotective effects in models of in cerebral ischemia that can be used for neurological disease research.

For research use only. We do not sell to patients.

CAS No.: 325819-97-4
Formula: C₂₁H₂₆ClF₂NO
Molecular Weight:381.89

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

LY393615 Chemical Structure

CAS No.: 325819-97-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target

P/Q-type calcium channel

4 μM (IC₅₀)

All Calcium Channel Isoforms :

All Sodium Channel Isoforms :

In Vitro

LY393615 (0-10 μΜ) inhibits calcium flux in HEK 293 cells with α1A and α1B calcium channel subunits with IC₅₀s of 1.9 μΜ and 5.2 μΜ, and inhibits P-type calcium channels in isolated Purkinje cells with IC₅₀ of 4.0 μΜ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

LY393615 (10 or 12.5 or 15 mg/kg; i.p., single dose) protects against hypoxiahypoglycaemic insults in brain slices and also provided significant protection against ischaemia-induced hippocampal damage in gerbil global cerebral ischaemiasup^[1]. LY393615 (15 mg/kg; i.p., 1 mg/kg; i.v.; single dose) has good brain penetration with T_1/2s of 2.04 hours (i.v.) and 2.5 hours (i.p.)^[1]. Pharmacokinetic parameters for LY393615 in Gerbils^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Gerbils global cerebral ischaemia^[1]
Dosage:

10, 12.5 or 15 mg/kg
Administration:

Intraperitoneal injection (i.p.)
Result:

Protected against hypoxiahypoglycaemic insults in brain slices and also provided significant protection against ischaemia-induced hippocampal damage in gerbil global cerebral ischaemia.

Animal Model:

Gerbils (Pharmacokinetic assay)^[1]
Dosage:

1.0 or 15 mg/kg
Administration:

Intraperitoneal injection (i.p.) ; Intravenous injection (i.v.)
Result:

Had good brain penetration with T_1/2s of 2.04 hours (i.v.) and 2.5 hours (i.p.)^[1].

Chemical Information

CAS No. 325819-97-4
Molecular Weight 381.89
Formula C₂₁H₂₆ClF₂NO
SMILES

FC1=CC=C(C2(C3=CC=C(F)C=C3)CCC(CNCCCC)O2)C=C1.[H]Cl
Synonyms

NCC1048
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. O'Neill MJ, et.al. LY393615, a novel neuronal Ca(2+) and Na(+) channel blocker with neuroprotective effects in models of in vitro and in vivo cerebral ischemia. Brain Res. 2001 Jan 5;888(1):138-149. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

Route	Dose (mg/kg)	T_1/2 (h)
i.v.	1	2.04
i.p.	15	2.5

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LY393615

All Calcium Channel Isoforms

All Sodium Channel Isoforms