1. Metabolic Enzyme/Protease
    Cell Cycle/DNA Damage
  2. Dihydroorotate Dehydrogenase
    DNA/RNA Synthesis
  3. DHODH-IN-15

DHODH-IN-15 

Cat. No.: HY-135679
Handling Instructions

DHODH-IN-15 (Compound 7b) is a hydroxyfurazan analog of A771726. DHODH-IN-15 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 11 μM for rat liver DHODH. DHODH-IN-15 can be used for rheumatoid arthritis.

For research use only. We do not sell to patients.

DHODH-IN-15 Chemical Structure

DHODH-IN-15 Chemical Structure

CAS No. : 1364791-88-7

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Description

DHODH-IN-15 (Compound 7b) is a hydroxyfurazan analog of A771726. DHODH-IN-15 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 11 μM for rat liver DHODH. DHODH-IN-15 can be used for rheumatoid arthritis[1].

IC50 & Target

IC50: 11 μM (Rat liver DHODH)[1]

In Vitro

DHODH-IN-15 (Compound 7b) is a hydroxyfurazan analog of A771726, in which the biphenyl scaffold does not bear any substituent. Moving to derivatives DHODH-IN-15, no major differences were observed among the poses obtained on 1UUO and 1D3G; in both cases DHODH-IN-15 is found to bind in a BQN-like fashion, namely with the deprotonated hydroxyfurazan moiety facing Arg136, thus effectively mimicking the carboxyl group of BQN and related compounds. While on 1D3G and 1UUO the hydroxyfurazan is in no case found to interact with Tyr356 in a Leflunomide-like fashion, a significant fraction of such poses is found when 2BXV is used as the docking target[1].

Molecular Weight

281.27

Formula

C₁₅H₁₁N₃O₃

CAS No.

1364791-88-7

SMILES

O=C(C1=NONC1=O)NC2=CC=C(C3=CC=CC=C3)C=C2

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DHODH-IN-15Dihydroorotate DehydrogenaseDNA/RNA SynthesisDHODHhydroxyfurazanLeflunomideA771726BQNratantiinflammatoryrheumatoidarthritisInhibitorinhibitorinhibit

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