Dimethyl lithospermate B
Based on 1 Customer Validation
Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist. Dimethyl lithospermate B slows inactivation of sodium current (INa), leading to increased inward current during the early phases of the action potential (AP).
For research use only. We do not sell to patients.
- Purity: 99.40%
- CAS No.: 875313-64-7
- Formula: C38H34O16
- Molecular Weight:746.67
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Na+ channel[1]
Chemical Information
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CAS No. 875313-64-7
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Appearance Solid
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Molecular Weight 746.67
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Formula C38H34O16
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Color White to off-white
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SMILES
OC1=C(O)C=CC(C[C@H](C(OC)=O)OC([C@H]2C3=C(/C=C/C(O[C@@H](C(OC)=O)CC4=CC(O)=C(O)C=C4)=O)C=CC(O)=C3O[C@@H]2C5=CC(O)=C(O)C=C5)=O)=C1
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Synonyms
dmLSB
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (133.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Fish JM, et al. Dimethyl lithospermate B, an extract of Danshen, suppresses arrhythmogenesis associated with the Brugada syndrome. Circulation. 2006 Mar 21;113(11):1393-400. [Content Brief]
[2]. Yoon JY, et al. A novel Na+ channel agonist, dimethyl lithospermate B, slows Na+ current inactivation and increases action potential duration in isolated rat ventricular myocytes. Br J Pharmacol. 2004 Nov;143(6):765-73. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3393 mL | 6.6964 mL | 13.3928 mL | 33.4820 mL |
| 5 mM | 0.2679 mL | 1.3393 mL | 2.6786 mL | 6.6964 mL | |
| 10 mM | 0.1339 mL | 0.6696 mL | 1.3393 mL | 3.3482 mL | |
| 15 mM | 0.0893 mL | 0.4464 mL | 0.8929 mL | 2.2321 mL | |
| 20 mM | 0.0670 mL | 0.3348 mL | 0.6696 mL | 1.6741 mL | |
| 25 mM | 0.0536 mL | 0.2679 mL | 0.5357 mL | 1.3393 mL | |
| 30 mM | 0.0446 mL | 0.2232 mL | 0.4464 mL | 1.1161 mL | |
| 40 mM | 0.0335 mL | 0.1674 mL | 0.3348 mL | 0.8370 mL | |
| 50 mM | 0.0268 mL | 0.1339 mL | 0.2679 mL | 0.6696 mL | |
| 60 mM | 0.0223 mL | 0.1116 mL | 0.2232 mL | 0.5580 mL | |
| 80 mM | 0.0167 mL | 0.0837 mL | 0.1674 mL | 0.4185 mL | |
| 100 mM | 0.0134 mL | 0.0670 mL | 0.1339 mL | 0.3348 mL |
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