Ebronucimab
Based on 1 Customer Validation
Ebronucimab (AK102) is an IgG1-λ2 antibody targeting PCSK9 and is primarily expressed by CHO DG44 (Chinese Hamster Ovary) cells.
For research use only. We do not sell to patients.
- CAS No.: 2304800-90-4
- Molecular Weight:144.74 kDa
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Storage:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Isotype
Human IgG1 lambda2
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
PCSK9
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG1 lambda
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized PCSK9 Protein, Human (HEK293, C-His, HY-P70545A) can bind Ebronucimab. The EC50 for this effect is 23.54 ng/mL. -
Flow Cytometry analysis of Hela cells labelling PCSK9 (red) with Ebronucimab (anti-PCSK9) (HY-P99871). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 lambda2 (HY-P990096, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
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CAS No. 2304800-90-4
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Appearance Liquid
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Molecular Weight 144.74 kDa
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Color Colorless to light yellow
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SMILES
[Ebronucimab]
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Synonyms
AK102
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (253 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Ebronucimab. IMGT.
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)