ID1 - inhibitor of DNA binding 1 Gene

Also Known as ID; bHLHb24

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3397

About ID1

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:31,605,289-31,606,510 (from NCBI)

This gene has 2 transcripts (splice variants), 207 orthologues and 3 paralogues. Broad expression in lung (RPKM 56.6), colon (RPKM 54.0) and 24 other tissues.

Summary

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ID1 Products (2)

mRNA	Protein	Name
NM_002165.4	NP_002156.2	DNA-binding protein inhibitor ID-1 isoform a
NM_181353.3	NP_851998.1	DNA-binding protein inhibitor ID-1 isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15694377	GOA
enables transcription regulator inhibitor activity	IDA IDA: Inferred from direct assay	7665172	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	7665172	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15138269	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7665172	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ID1 Protein Structure

HLH

0
100
155 a.a.

Protein Preferred Names	Protein Names
DNA-binding protein inhibitor ID-1	class B basic helix-loop-helix protein 24

ID1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ID1	P41134	TCF12	Homo sapiens	Q99081-3	Y2H Array	32296183
Intra	ID1	P41134	TCF12	Homo sapiens	Q99081-3	Y2H Prey Pooling	32296183
Intra	ID1	P41134	TCF12	Homo sapiens	Q99081-3	Validated Y2H	32296183
Intra	ID1	P41134	TCF3	Homo sapiens	P15923-3	Y2H Array	32296183
Intra	ID1	P41134	TCF3	Homo sapiens	P15923-3	Y2H Prey Pooling	32296183
Intra	ID1	P41134	ASCL3	Homo sapiens	Q9NQ33	Y2H Prey Pooling	32296183
Intra	ID1	P41134	ASCL3	Homo sapiens	Q9NQ33	Validated Y2H	32296183
Intra	ID1	P41134	ASCL3	Homo sapiens	Q9NQ33	Y2H Array	32296183
Intra	ID1	P41134	CASK	Homo sapiens	O14936	Anti Bait CoIP	15694377
Intra	ID1	P41134	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183
Intra	ID1	P41134	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	ID1	P41134	MYF5	Homo sapiens	P13349	Y2H Prey Pooling	32296183
Intra	ID1	P41134	MYF5	Homo sapiens	P13349	Y2H Array	32296183
Intra	ID1	P41134	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	ID1	P41134	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	ID1	P41134	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	ID1	P41134	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	ID1	P41134	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	ID1	P41134	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	ID1	P41134	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	ID1	P41134	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	ID1	P41134	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	ID1	P41134	MYOG	Homo sapiens	P15173	Y2H Array	32296183
Intra	ID1	P41134	MYOG	Homo sapiens	P15173	Y2H Prey Pooling	32296183
Intra	ID1	P41134	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	ID1	P41134	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	ID1	P41134	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	ID1	P41134	CAV1	Homo sapiens	Q03135	Y2H	17855368
Intra	ID1	P41134	CAV1	Homo sapiens	Q03135	Anti Bait CoIP	17855368
Intra	ID1	P41134	CAV1	Homo sapiens	Q03135	IF	17855368
Intra	ID1	P41134	TCF12	Homo sapiens	Q99081	Y2H Array	20211142
Intra	ID1	P41134	TCF12	Homo sapiens	Q99081	Anti Tag CoIP	26496610

Cross: Cross-species interaction Intra: Intraspecies interaction

ID1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83100	ID1 Antibody (YA2845)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Mouth Disease	Mouth Diseases Mouth Disorders
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Hemangioma	Hemangiomas
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Fibrodysplasia Ossificans Progressiva	Myositis Ossificans Progressiva Progressive Myositis Ossificans FOP Progressive Ossifying Myositis Myositis Ossificans Stone Man Syndrome Man Of Stone Myositis Ossificans Progressive Diffuse Progressive Ossifying Polymyositis Fibrodysplasia Ossificans Congenita Myositis Ossificans Progressiva, Site Unspecified Münchmeyer Disease Fop - [Fibrodysplasia Ossificans Progressiva] Progressive Myositis Ossificans Calcification
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Hereditary Hemorrhagic Telangiectasia	Rendu-Osler-Weber Disease Hht Osler-Weber-Rendu Disease Telangiectasia, Hereditary Hemorrhagic Osler Hemorrhagic Telangiectasia Syndrome Orw Disease Osler Weber Rendu Syndrome Osler-Rendu-Weber Disease Osler-Weber-Rendu Syndrome Rendu-Osler Disease Telangiectasia Hereditary Hemorrhagic Telangiectasia Hemorrhagic, Hereditary Hht - [Hereditary Haemorrhagic Telangiectasia] Osler Haemorrhagic Telangiectasia Syndrome
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124697	BMP signaling agonist sb4	Agonist	99.98%	Unkown
HY-129241	AGX51	Antagonist	99.33%	Unkown
HY-80012	SJB3-019A	Inhibitor	99.88%	Unkown
HY-110245	DMH2	Inducer	99.84%	Unkown
HY-RS06522	ID1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06528	Idh1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16689	Id1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23124	Id1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ID1	VGNC	VGNC:73556
Mus musculus	ID1	MGD	MGI:96396
Rattus norvegicus	ID1	RGD	RGD:2858
Bos taurus	ID1	VGNC	VGNC:30031
Felis catus	ID1	VGNC	VGNC:67692
Others	ID1	NCBI