MAPKAPK2 - MAPK activated protein kinase 2 Gene

Also Known as MK2; MK-2; MAPKAP-K2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9261

About MAPKAPK2

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,684,905-206,734,281 (from NCBI)

This gene has 4 transcripts (splice variants), 238 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 54.9), heart (RPKM 45.1) and 25 other tissues.

Summary

This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

MAPKAPK2 Products (5)

mRNA	Protein	Name
NM_004759.5	NP_004750.1	MAP kinase-activated protein kinase 2 isoform 1
XM_047434418.1	XP_047290374.1	MAP kinase-activated protein kinase 2 isoform X3
XM_005273353.4	XP_005273410.1	MAP kinase-activated protein kinase 2 isoform X1
XM_017002810.2	XP_016858299.1	MAP kinase-activated protein kinase 2 isoform X2
NM_032960.4	NP_116584.2	MAP kinase-activated protein kinase 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	8774846	GOA
enables protein serine/threonine kinase activity	EXP EXP: Inferred from Experiment	7799959	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	8774846	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in 3'-UTR-mediated mRNA stabilization	IDA IDA: Inferred from direct assay	14517288	GOA
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	20932473	GOA
involved in cellular response to vascular endothelial growth factor stimulus	IMP IMP: Inferred from mutant phenotype	18440775	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	15850461	GOA
involved in regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	15014438	GOA
involved in response to cytokine	IDA IDA: Inferred from direct assay	8774846	GOA
involved in vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18440775	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	20932473	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20932473	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPKAPK2 Protein Structure

Pkinase

0
100
200
300
400 a.a.

Protein Preferred Names	Protein Names
MAP kinase-activated protein kinase 2	MAPKAP kinase 2 mitogen-activated protein kinase-activated protein kinase 2

MAPKAPK2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MAPKAPK2	P49137	HSPB1	Homo sapiens	P04792	Protein Kinase Assay	21575178
Cross	MAPKAPK2	P49137	Phc2	Mus musculus	Q9QWH1	Pull Down	19369945
Intra	MAPKAPK2	P49137	HSF1	Homo sapiens	Q00613	GMS	16278218
Intra	MAPKAPK2	P49137	MAPK14	Homo sapiens	Q16539	Y2H	21988832
Intra	MAPKAPK2	P49137	MAPK14	Homo sapiens	Q16539	PLA	25241761
Intra	MAPKAPK2	P49137	MAPK14	Homo sapiens	Q16539	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

MAPKAPK2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80214	MAPKAPK2 Antibody (YA304)	WB	Human, Mouse, Rat
HY-P80214A	MAPKAPK2 Antibody (YA304)(PBS only)	WB	Human, Mouse, Rat
HY-P83774	Phospho-MAPKAPK2 (Thr334) Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P86156	MAPKAPK2 Antibody (YA5848)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Monocytic Leukemia	Monocytic Leukaemia Schilling'S Leukaemia Schilling'S Leukemia M5b Acute Differentiated Monocytic Leukemia
Retinitis Pigmentosa 58	RP58 Retinitis Pigmentosa, Type 58

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16129	CBP-501	Inhibitor	99.75%	Phase 2
HY-16129A	CBP-501 acetate	Inhibitor	99.75%	Phase 2

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107427	PF-3644022	Inhibitor	99.91%	Unkown
HY-131249	MK2-IN-3	Inhibitor	99.15%	Unkown
HY-12834A	MK2-IN-1 hydrochloride	Inhibitor	98.36%	Unkown
HY-112457	MK2-IN-3 hydrate	Inhibitor	99.08%	Unkown
HY-148061	DB1113		99.86%	Unkown
HY-12834	MK2-IN-1	Inhibitor	99.04%	Unkown
HY-148063	DB0614		99.92%	Unkown
HY-147283	MK2-IN-4	Inhibitor	/	Unkown
HY-175809	SRT6	Inhibitor	/	Unkown
HY-182596	INHIB1X	Inhibitor	/	Unkown
HY-P10367	Ziptide		/	Unkown
HY-RS08131	MAPKAPK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08132	Mapkapk2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08133	Mapkapk2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MAPKAPK2	VGNC	VGNC:54449
Rattus norvegicus	MAPKAPK2	RGD	RGD:631362
Macaca mulatta	MAPKAPK2	VGNC	VGNC:74653
Mus musculus	MAPKAPK2	MGD	MGI:109298
Felis catus	MAPKAPK2	VGNC	VGNC:68175
Canis familiaris	MAPKAPK2	VGNC	VGNC:43006
Others	MAPKAPK2	NCBI