Laminaran
Based on 2 publication(s) in Google Scholar
Laminaran is an β-1-3-glucan and a typical ligand for Dectin-1 from Eisenia Bicyclis, has potent immunomodulating, radioprotective, and anticancer activities. Laminaran is made up of β (1→3)-glucan with β (1→6)-branches and can be catalyzed by enzymes such as laminarinase (EC 3.2.1.6) that breaks the β (1→3) bonds. Laminaran is a promising immune stimulatory molecule for use in cancer immunotherapy.
For research use only. We do not sell to patients.
- CAS No.: 9008-22-4
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Immunology/Inflammation Compound Library
HY-L007
-
Metabolism/Protease Compound Library
HY-L012
-
Natural Product Library
HY-L021
-
Anti-Cancer Compound Library
HY-L025
-
Microbial Metabolite Library
HY-L084
-
Anti-Cancer Natural Product Library
HY-L107
-
Plant-Sourced Natural Product Library
HY-L115
-
Heterocyclic Compound Library
HY-L138
-
Radioprotector Library
HY-L178
-
Bioactive Compound Library Max
HY-L181
-
Natural Product Library Plus
HY-L021P
-
Natural Product and Natural Product-Like Compound Library
HY-L021M
-
Bioactive Compound Library
HY-L001
-
Pesticide Compound Library
HY-L183
-
High-Throughput Bioactive Compound Library
HY-L205
-
High-Throughput Natural Product Library
HY-L206
-
Polysaccharides Compound Library
HY-L216
-
Pattern Recognition Receptors Library
HY-L237
-
Environmental Pollutant Compound Library
HY-L247
Publications Citing Use of MedChemExpress (MCE) Laminaran
More
Customer Validation & Images
-
Bio/Physico-chemical Assay
-
RT-PCR
-
ELISA
-
RT-PCR
-
Histological Imaging/Staining
All Endogenous Metabolite Isoforms
More
Biological Activity
|
Dectin-1 |
Laminaran (100-800 μg/mL; 24 hours) is not cytotoxic against normal epidermal cells JB6 Cl41 and human melanoma cells SK-MEL-28, the percentage of inhibition of living cells number is less than 15 % at concentrations range up to 800 μg/mL after 24 h of treatment[1]. Laminaran (200 μg/mL; 24-72 hours)does not cause any growth inhibition of SK-MEL-28 cells after 24 and 48 h of treatment, but decreases cells proliferation by 36 % after 72 h of treatment[1]. Laminaran (25-50 μg/mL; 24 hours) at low concentration does not influence the phosphorylation of c-Raf (Ser259), ERK1/2 (Tyr202/Tyr204), and MEK1/2 (Ser 221) kinases as well as total expression level of investigated proteins. But decreases p-MEK, p-ERK1/2 at 50 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:JB6 Cl41 and SK-MEL-28 cells
-
Concentration:100, 200, 400, and 800 µg/mL
-
Incubation Time:24 hours
-
Result:Showed no cytotoxic against normal epidermal cells JB6 Cl41 and human melanoma cells SK-MEL-28.
-
Cell Line:SK-MEL-28 cells
-
Concentration:200 µg/mL
-
Incubation Time:24 hours
-
Result:Decreased cell proliferation at 72 hours.
-
Cell Line:SK-MEL-28 cells
-
Concentration:25 µg/mL; 50 µg/mL
-
Incubation Time:24 hours
-
Result:Inhibited phosphorylation of c-Raf, MEK1/2, and ERK1/2 kinases.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6 mice injected s.c. with B16-OVA cells[3]
-
Dosage:12.5, 25, and 50 mg/kg; 21 days
-
Administration:Intravenous injection
-
Result:Prevented B16-OVA tumor growth by inducing Ag-specific immune responses.
Chemical Information
-
CAS No. 9008-22-4
-
Appearance Solid
-
Color White to off-white
-
SMILES
[Laminaran]
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Int Immunopharmacol
2025 Jan 9:147:114014. PMID: 39793225
Laminaran purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Jan 9:147:114014. [Abstract]
Laminaran (100 μM) treatment significantly increased the HTDNA-induced expression of IFNB in Hela cells.
Laminaran purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Jan 9:147:114014. [Abstract]
Laminaran (50-500 µM; 6 h) increased mRNA expression level of IFNB in THP-1 cells stimulated with HTDNA.
Laminaran purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Jan 9:147:114014. [Abstract]
Laminaran (100 µM; 6 h) increased IFN-β production in THP-1 cells stimulated with HTDNA.
Laminaran purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Jan 9:147:114014. [Abstract]
Laminaran (100 µM; 6 h) increased mRNA expression levels of CXCL10 and ISG56 in THP-1 cells stimulated with HTDNA.
Laminaran purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Jan 9:147:114014. [Abstract]
Laminaran (25 mg/kg; i.v.; once daily for 3 weeks) decreased inflammatory cell infiltration and tissue damage in the lung of C57BL/6J mice after HSV-1 infection.
-
Solvent & Solubility
H2O : 16.67 mg/mL (Need ultrasonic)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 33.33 mg/mL; Clear solution; Need ultrasonic
Purity & Documentation
-
Data Sheet (273 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Malyarenko OS, et al. Laminaran from brown alga Dictyota dichotoma and its sulfated derivative as radioprotectors and radiosensitizers in melanoma therapy.Carbohydr Polym. 2019 Feb 15;206:539-547. [Content Brief]
[2]. Laminaran
[3]. Song K, et al. Laminarin promotes anti-cancer immunity by the maturation of dendritic cells.Oncotarget. 2017 Jun 13;8(24):38554-38567. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Laminaran Related Classifications
HY-119109 Related Classifications
Powered by Bioz