UM206_C
UM206_C is a circular Wnt fragment peptide derived from conserved Wnt3a/Wnt5a sequences, inactive in soluble form but capable of activating canonical Wnt/β-catenin signaling when conjugated to magnetic nanoparticles and exposed to a high-gradient, time-varying magnetic field or immobilized on glass surfaces.
For research use only. We do not sell to patients.
- CAS No.: 1242439-01-5
- Formula: C54H88N16O23S3
- Molecular Weight:1425.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
UM206_C (free form) (10 nM-1 mM; 3 h, 24 h) fails to stably regulate the canonical Wnt/β-catenin TCF/LEF signaling pathway in HEK293 Luc-TCF/LEF cells[1].
UM206_C-conjugated MNPs (1-10 µg per mg MNP; 1-24 h), when combined with 1 Hz nanomagnetic actuation, potently activate the canonical Wnt/β-catenin TCF/LEF signaling pathway in HEK293 Luc-TCF/LEF cells in a peptide density-dependent manner in vitro[1].
UM206_C (immobilized; 1 µg per slide; 3-24 h) retains weak canonical Wnt/β-catenin TCF/LEF signaling activity in HEK293 Luc-TCF/LEF cells on glass substrates, induces a significant increase in signaling at 3 h, and this signaling level is maintained until 24 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1242439-01-5
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Molecular Weight 1425.56
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Formula C54H88N16O23S3
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Sequence
Ac-Cys-Asn-Lys-Thr-Ser-Glu-Gly-Met-Asp-Gly-Cys-Glu-Leu-NH2 (disulfide bridge:Cys1-Cys11)
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Sequence Shortening
Ac-CNKTSEGMDGCEL-NH2 (disulfide bridge:Cys1-Cys11)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)