2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. DS43260857

DS43260857 is a potentNaV1.7inhibitor, which has a high inhibitory effect on both human and mouse NaV1.7. The IC50 values of DS43260857 for hNaV1.1, hNaV1.5, hNaV1.7, mNaV1.7 are 6.6, 14, 0.015 and 0.061 μM, respectively.

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DS43260857 Chemical Structure

DS43260857 Chemical Structure

CAS No. : 1612158-07-2

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Description

DS43260857 is a potentNaV1.7inhibitor, which has a high inhibitory effect on both human and mouse NaV1.7. The IC50 values of DS43260857 for hNaV1.1, hNaV1.5, hNaV1.7, mNaV1.7 are 6.6, 14, 0.015 and 0.061 μM, respectively[1].

IC50 & Target

IC50:6.6μM(hNaV1.1),14μM(hNaV1.5), 0.015μM(mNaV1.7),0.061μM(mNaV1.7)[1]
Molecular Weight

423.41

Formula

C19H16F3N3O3S
CAS No.
SMILES

CC1=CN(C2=CC(C(F)(F)F)=CN=C2)C3=C1C=C(C(NS(C4CC4)(=O)=O)=O)C=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DS43260857 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DS432608571612158-07-2DS 43260857DS-43260857Sodium ChannelNa channelsNa+ channelsNaV1.7,hNaV1.1,hNaV1.5,hNaV1.7,mNaV1.7Inhibitorinhibitorinhibit

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