2. Protein Tyrosine Kinase/RTK
  3. DYRK
  4. DYRK2-IN-1

DYRK2-IN-1 (Compd 54) is an orally bioavailable DYRK2 inhibitor, with an IC50 of 14 nM. DYRK2-IN-1 (Compd 54) can be used in the study of prostate cancer.

For research use only. We do not sell to patients.

DYRK2-IN-1

DYRK2-IN-1 Chemical Structure

CAS No. : 3036481-22-5

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DYRK2-IN-1 Related Antibodies

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DYRK1 DYRK2 DYRK3 DYRK4 HIPK PRP4

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Description

DYRK2-IN-1 (Compd 54) is an orally bioavailable DYRK2 inhibitor, with an IC50 of 14 nM. DYRK2-IN-1 (Compd 54) can be used in the study of prostate cancer[1].

IC50 & Target

IC50: 14 nM (DYRK2)[1].
Cellular Effect
Cell Line Type Value Description References
CWR22R GI50
4.38 μM
Compound: 54
Antiproliferative activity against human 22Rv1 cells assessed as growth inhibition incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human 22Rv1 cells assessed as growth inhibition incubated for 72 hrs by CCK8 assay
[PMID: 38033250]
DU-145 GI50
7.461 μM
Compound: 54
Antiproliferative activity against human DU-145 cells assessed as growth inhibition incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human DU-145 cells assessed as growth inhibition incubated for 72 hrs by CCK8 assay
[PMID: 38033250]
PC-3 GI50
8.043 μM
Compound: 54
Antiproliferative activity against human PC-3 cells assessed as growth inhibition incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human PC-3 cells assessed as growth inhibition incubated for 72 hrs by CCK8 assay
[PMID: 38033250]
RWPE-1 GI50
67.06 μM
Compound: 54
Antiproliferative activity against human RWPE-1 cells assessed as growth inhibition incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human RWPE-1 cells assessed as growth inhibition incubated for 72 hrs by CCK8 assay
[PMID: 38033250]
Molecular Weight

574.67

Formula

C29H31FN8O2S
CAS No.
SMILES

FC1=CN=C(N=C1C2=CC=C3N=C(SC3=C2)N(CC)CC)NC4=NC=C(C=C4)C(N5CCN(CC5)C(C6CC6)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DYRK2-IN-1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DYRK2-IN-13036481-22-5DYRKDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseInhibitorinhibitorinhibit

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