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Cat. No.: HY-161014

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DYRK2-IN-1

DYRK2-IN-1 (Compd 54) is an orally bioavailable DYRK2 inhibitor, with an IC₅₀ of 14 nM. DYRK2-IN-1 (Compd 54) can be used in the study of prostate cancer.

For research use only. We do not sell to patients.

CAS No.: 3036481-22-5
Formula: C₂₉H₃₁FN₈O₂S
Molecular Weight:574.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

DYRK2-IN-1 Chemical Structure

CAS No.: 3036481-22-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

DYRK2-IN-1 (Compd 54) is an orally bioavailable DYRK2 inhibitor, with an IC₅₀ of 14 nM. DYRK2-IN-1 (Compd 54) can be used in the study of prostate cancer^[1].

IC₅₀ & Target

IC50: 14 nM (DYRK2)^[1].

All DYRK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CWR22R	GI₅₀	4.38 μM Compound: 54	Antiproliferative activity against human 22Rv1 cells assessed as growth inhibition incubated for 72 hrs by CCK8 assay Antiproliferative activity against human 22Rv1 cells assessed as growth inhibition incubated for 72 hrs by CCK8 assay	[PMID: 38033250]
DU-145	GI₅₀	7.461 μM Compound: 54	Antiproliferative activity against human DU-145 cells assessed as growth inhibition incubated for 72 hrs by CCK8 assay Antiproliferative activity against human DU-145 cells assessed as growth inhibition incubated for 72 hrs by CCK8 assay	[PMID: 38033250]
PC-3	GI₅₀	8.043 μM Compound: 54	Antiproliferative activity against human PC-3 cells assessed as growth inhibition incubated for 72 hrs by CCK8 assay Antiproliferative activity against human PC-3 cells assessed as growth inhibition incubated for 72 hrs by CCK8 assay	[PMID: 38033250]
RWPE-1	GI₅₀	67.06 μM Compound: 54	Antiproliferative activity against human RWPE-1 cells assessed as growth inhibition incubated for 72 hrs by CCK8 assay Antiproliferative activity against human RWPE-1 cells assessed as growth inhibition incubated for 72 hrs by CCK8 assay	[PMID: 38033250]

Chemical Information

CAS No. 3036481-22-5
Molecular Weight 574.67
Formula C₂₉H₃₁FN₈O₂S
SMILES

FC1=CN=C(N=C1C2=CC=C3N=C(SC3=C2)N(CC)CC)NC4=NC=C(C=C4)C(N5CCN(CC5)C(C6CC6)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kai Yuan, et al. Discovery of Potent, Selective, and Orally Bioavailable DYRK2 Inhibitors for the Treatment of Prostate Cancer. J Med Chem. 2023 Dec 14;66(23):16235-16256. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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DYRK2-IN-1

All DYRK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

DYRK2-IN-1 Related Classifications

HY-161014 Related Classifications