country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-161014

Copy Link Print Information

DYRK2-IN-1

DYRK2-IN-1 (Compd 54) is an orally bioavailable DYRK2 inhibitor, with an IC₅₀ of 14 nM. DYRK2-IN-1 (Compd 54) can be used in the study of prostate cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 3036481-22-5
分子式: C₂₉H₃₁FN₈O₂S
分子量:574.67

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

DYRK2-IN-1 構造式

CAS 番号: 3036481-22-5

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

DYRK2-IN-1 (Compd 54) is an orally bioavailable DYRK2 inhibitor, with an IC₅₀ of 14 nM. DYRK2-IN-1 (Compd 54) can be used in the study of prostate cancer^[1].

IC₅₀ & Target

IC50: 14 nM (DYRK2)^[1].

DYRK アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
CWR22R	GI₅₀	4.38 μM Compound: 54	Antiproliferative activity against human 22Rv1 cells assessed as growth inhibition incubated for 72 hrs by CCK8 assay Antiproliferative activity against human 22Rv1 cells assessed as growth inhibition incubated for 72 hrs by CCK8 assay	[PMID: 38033250]
DU-145	GI₅₀	7.461 μM Compound: 54	Antiproliferative activity against human DU-145 cells assessed as growth inhibition incubated for 72 hrs by CCK8 assay Antiproliferative activity against human DU-145 cells assessed as growth inhibition incubated for 72 hrs by CCK8 assay	[PMID: 38033250]
PC-3	GI₅₀	8.043 μM Compound: 54	Antiproliferative activity against human PC-3 cells assessed as growth inhibition incubated for 72 hrs by CCK8 assay Antiproliferative activity against human PC-3 cells assessed as growth inhibition incubated for 72 hrs by CCK8 assay	[PMID: 38033250]
RWPE-1	GI₅₀	67.06 μM Compound: 54	Antiproliferative activity against human RWPE-1 cells assessed as growth inhibition incubated for 72 hrs by CCK8 assay Antiproliferative activity against human RWPE-1 cells assessed as growth inhibition incubated for 72 hrs by CCK8 assay	[PMID: 38033250]

化学情報

CAS 番号 3036481-22-5
分子量 574.67
分子式 C₂₉H₃₁FN₈O₂S
SMILES

FC1=CN=C(N=C1C2=CC=C3N=C(SC3=C2)N(CC)CC)NC4=NC=C(C=C4)C(N5CCN(CC5)C(C6CC6)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (265 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Kai Yuan, et al. Discovery of Potent, Selective, and Orally Bioavailable DYRK2 Inhibitors for the Treatment of Prostate Cancer. J Med Chem. 2023 Dec 14;66(23):16235-16256. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ

Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
日本の代理先をお選びください:

製品名:
CAS 番号:
生物種:
純度:
数量:

DYRK2-IN-1

DYRK アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

DYRK2-IN-1 関連分類

HY-161014 関連分類