2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. E-3620

E-3620 is a potent 5-HT3 receptor antagonist. E-3620 can be used for the research of dyskinesi and gastrointestinal motility.

For research use only. We do not sell to patients.

E-3620 Chemical Structure

E-3620 Chemical Structure

CAS No. : 151213-86-4

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5 mg USD 610 In-stock
10 mg USD 950 In-stock
25 mg USD 1900 In-stock
50 mg USD 3050 In-stock
100 mg USD 4880 In-stock
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Based on 1 publication(s) in Google Scholar

E-3620 Related Antibodies

Top Publications Citing Use of Products

View All 5-HT Receptor Isoform Specific Products:

View All Isoforms
5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

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  • Purity & Documentation

  • References

  • Customer Review

Description

E-3620 is a potent 5-HT3 receptor antagonist. E-3620 can be used for the research of dyskinesi and gastrointestinal motility[1][2].

IC50 & Target

5-HT3 Receptor

 

Molecular Weight

412.35

Formula

C20H27Cl2N3O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N[C@@H]1C[C@@H](N2C)CC[C@@H]2C1)C3=CC(Cl)=C(N)C=C3O[C@@H](C)C#CC.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (242.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4251 mL 12.1256 mL 24.2512 mL
5 mM 0.4850 mL 2.4251 mL 4.8502 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4251 mL 12.1256 mL 24.2512 mL 60.6281 mL
5 mM 0.4850 mL 2.4251 mL 4.8502 mL 12.1256 mL
10 mM 0.2425 mL 1.2126 mL 2.4251 mL 6.0628 mL
15 mM 0.1617 mL 0.8084 mL 1.6167 mL 4.0419 mL
20 mM 0.1213 mL 0.6063 mL 1.2126 mL 3.0314 mL
25 mM 0.0970 mL 0.4850 mL 0.9700 mL 2.4251 mL
30 mM 0.0808 mL 0.4042 mL 0.8084 mL 2.0209 mL
40 mM 0.0606 mL 0.3031 mL 0.6063 mL 1.5157 mL
50 mM 0.0485 mL 0.2425 mL 0.4850 mL 1.2126 mL
60 mM 0.0404 mL 0.2021 mL 0.4042 mL 1.0105 mL
80 mM 0.0303 mL 0.1516 mL 0.3031 mL 0.7579 mL
100 mM 0.0243 mL 0.1213 mL 0.2425 mL 0.6063 mL
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E-3620 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E-3620151213-86-4E3620E 36205-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptordyskinesia5-HT3gastrointestinal motilityInhibitorinhibitorinhibit

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