(4R,5S)-Nutlin carboxylic acid
(4R,5S)-Nutlin carboxylic acid is a MDM2 ligand and also a nutlin-3 derivative. (4R,5S)-Nutlin carboxylic acid can be linked to target protein ligands via a linker to form a PROTAC that can be used for targeting PARP1.
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- CAS. Nr.: 2306390-08-7
- Formel: C32H32Cl2N4O6
- Molecular Weight:639.53
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
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HY-128837
Nutlin carboxylic acidMDM2 Ligand -
HY-103597
Thalidomide-O-COOHCereblon Ligand -
HY-41547
Thalidomide 4-fluorideLigands for E3 Ligase -
HY-112078
(S,R,S)-AHPC-MeLigands for E3 Ligase -
HY-103596
Thalidomide-4-OHCereblon Ligand -
HY-42424
(S,R,S)-AHPC-Me hydrochlorideLigands for E3 Ligase -
HY-128808
cIAP1 ligand 1cIAP1 Ligand -
HY-43961
E3 ligase Ligand 8Ligands for E3 Ligase -
HY-125845
(S,R,S)-AHPCVHL Ligand -
HY-101763A
(S,R,S)-AHPC monohydrochlorideVHL Ligand -
HY-111663
VL285VHL Ligand -
HY-125845A
(S,S,S)-AHPC hydrochlorideVHL Building Block
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
MDM2 |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.\t\t
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS. Nr. 2306390-08-7
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Molecular Weight 639.53
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Formel C32H32Cl2N4O6
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SMILES
O=C1N(CC(O)=O)CCN(C(N2[C@@H](C3=CC=C(Cl)C=C3)[C@@H](C4=CC=C(Cl)C=C4)N=C2C5=CC=C(OC)C=C5OC(C)C)=O)C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
(4R,5S)-Nutlin carboxylic acid Related Classifications
HY-128836 Related Classifications
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