EGFR-IN-216
EGFR-IN-216 is an epidermal growth factor receptor (EGFR) tyrosine kinase (TK) inhibitor. EGFR-IN-216 inhibits EGFR tyrosine kinase phosphorylation, blocks downstream signaling pathway activation, suppresses cancer cell proliferation and promotes tumor cell apoptosis (apoptosis). EGFR-IN-216 can be used for the research of non-small cell lung cancer.
For research use only. We do not sell to patients.
- CAS No.: 1923767-20-7
- Formula: C23H26ClF2N3O5
- Molecular Weight:497.92
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All EGFR Isoforms
More
Biological Activity
EGFR-IN-216 (MPGF) (0.01-40 μM; 48 h) potently inhibits the viability of PC-9, a non-small cell lung cancer cell line carrying the EGFR exon 19 deletion mutation, with an IC50 of 2.5938 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:PC-9 cells
-
Concentration:0.01, 0.1, 1.25, 2.5, 5, 10, 20, 30, 40 μM
-
Incubation Time:48 h
-
Result:Potently inhibited the viability of PC-9 cells, with an IC50 of 2.5938 μM, showing a statistically significant inhibitory effect.
Chemical Information
-
CAS No. 1923767-20-7
-
Molecular Weight 497.92
-
Formula C23H26ClF2N3O5
-
SMILES
FC1=CC=C(NC2=C3C=C(OC)C(OCCOCCOCCOCCF)=CC3=NC=N2)C=C1Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR-IN-216 Related Classifications
HY-187334 Related Classifications
Powered by Bioz