2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EMI48

EMI48, the derivative of EMI1, displays greater potency toward mutant EGFR than EMI1. EMI48 inhibits EGFR triple mutants.

For research use only. We do not sell to patients.

EMI48 Chemical Structure

EMI48 Chemical Structure

CAS No. : 34564-13-1

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 330 In-stock
Solution
10 mM * 1 mL in DMSO USD 330 In-stock
Solid
5 mg USD 300 In-stock
10 mg USD 480 In-stock
50 mg USD 1400 In-stock
100 mg USD 2000 In-stock
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500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

EMI48 Related Antibodies

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • Biological Activity

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Description

EMI48, the derivative of EMI1, displays greater potency toward mutant EGFR than EMI1. EMI48 inhibits EGFR triple mutants[1].

IC50 & Target[1]

EGFRL858R/T790M/C797S

 

EGFRdel19 T790M C797S

 

In Vitro

EMI48 inhibits EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S. EMI48 can be used in the research of mutant EGFR-associated, drug-resistant non-small-cell lung cancer (NSCLC)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EMI48 Related Antibodies
Molecular Weight

348.40

Formula

C21H20N2O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CCN(CC)C1=CC=C2C(OC(C(C3=NC(C=C(C)C=C4)=C4O3)=C2)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 9.26 mg/mL (26.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8703 mL 14.3513 mL 28.7026 mL
5 mM 0.5741 mL 2.8703 mL 5.7405 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8703 mL 14.3513 mL 28.7026 mL 71.7566 mL
5 mM 0.5741 mL 2.8703 mL 5.7405 mL 14.3513 mL
10 mM 0.2870 mL 1.4351 mL 2.8703 mL 7.1757 mL
15 mM 0.1914 mL 0.9568 mL 1.9135 mL 4.7838 mL
20 mM 0.1435 mL 0.7176 mL 1.4351 mL 3.5878 mL
25 mM 0.1148 mL 0.5741 mL 1.1481 mL 2.8703 mL
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EMI48 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EMI4834564-13-1EMI 48EMI-48EGFREpidermal growth factor receptorErbB-1HER1derivativeex19delT790MC797SL858RNSCLCInhibitorinhibitorinhibit

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