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Cat. No.: HY-184732

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ERα-IN-3

ERα-IN-3 is a ERα inhibitor with an IC₅₀ of 74.48 μM. ERα-IN-3 induces cell cycle arrest at the G0/G1 and G2/M checkpoints and triggers Apoptosis. ERα-IN-3 exhibits anticancer effects against ER-positive breast cancer. ERα-IN-3 can be used for the research of ERα-positive breast cancer.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₂₅H₂₁N₃O₄
Masse moléculaire:427.45

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

ERα-IN-3 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target

^[1]

ERα

74.48 μM (IC₅₀)

Voir tous les produits spécifiques à Isoform Estrogen Receptor/ERR :

In Vitro

Anti-cancerApoptosisCell Cycle Regulation

Anti-cancer

ERα-IN-3 (Compound 20) at concentrations of 2-32 μM potently inhibits the proliferation of ER-positive breast cancer cell line T-47D, with an IC₅₀ value of 9.666 μM. Its activity in this cell line is superior to that of Tamoxifen (HY-13757A) and Bazedoxifene (HY-A0031)^[1].
ERα-IN-3 inhibits ERα with an IC₅₀ value of 74.48 μM^[1].

Anti-cancer

Apoptosis

ERα-IN-3 (25 μM; 48 h) induces apoptosis in approximately 40% of T-47D breast cancer cells^[1].

Anti-cancer

Cell Cycle Regulation

ERα-IN-3 (25 μM; 48 h) induces cell cycle arrest in T-47D cells, primarily at the G0/G1 phase (59.7%), with additional arrest at the G2/M phase (26.3%)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

T-47D
Concentration:

25 μM
Incubation Time:

48 h
Result:

Induced cell cycle arrest with 59.7% of cells in the G0/G1 phase, 9.8% in the S phase, and 26.3% in the G2/M phase.

Apoptosis Analysis^[1]

Cell Line:

T-47D
Concentration:

25 μM
Incubation Time:

48 h
Result:

Induced total apoptosis in approximately 40% of T-47D cells.
Showed early and late apoptotic populations lower than those induced by compound 21 and bazedoxifene but higher than those induced by tamoxifen.

Related Protocols :

Chemical Information

Masse moléculaire 427.45
Formule C₂₅H₂₁N₃O₄
SMILES

O=[N+](C1=CC(C2=NOC(C3=CN(CC4=CC=CC(OC)=C4)C5=C3C=CC=C5)C2)=CC=C1)[O-]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Das A, et al. Design, synthesis, in vitro and in silico evaluation of novel 5-(1-benzyl-1H-indol-3-yl)-3-phenyl-4,5-dihydroisoxazole derivatives against ER-positive breast cancer. Bioorg Chem. 2026 Jun 15;180:110103. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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ERα-IN-3

Voir tous les produits spécifiques à Isoform Estrogen Receptor/ERR

Activité biologique

Description

IC50 & Target

In Vitro

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

ERα-IN-3 Related Classifications

HY-184732 Related Classifications

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