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Cat. No.: HY-187621

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ERα ligand 6

ERα ligand 6 is an amino intermediate derived from OBHSA, and also serves as a precursor for the synthesis of ERα-targeted hydrophobic tag degraders, such as the ERα ligand moiety of ERα/RAD51 degrader 1 (HY-187096).

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화학식: C₂₉H₂₆F₃NO₈S
분자량:605.58

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

ERα ligand 6 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
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Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

ERα

All Estrogen Receptor/ERR Isoforms :

In Vitro

ERα ligand 6 is an amino intermediate derived from OBHSA, which serves as the ERα ligand moiety of ERα/RAD51 degrader 1 (HY-187096). ERα/RAD51 degrader 1 is a HyT degrader targeting ERα and RAD51, which drives the degradation of ERα and RAD51 via the ubiquitin-proteasome pathway. ERα/RAD51 degrader 1 acts on both Tamoxifen (HY-13757A)-sensitive and Tamoxifen-resistant breast cancer^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 605.58
화학식 C₂₉H₂₆F₃NO₈S
SMILES

O=S(N(C1=CC=C(C=C1)OCCC(O)=O)CC(F)(F)F)(C2C[C@@H]3C(C4=CC=C(O)C=C4)=C(C5=CC=C(O)C=C5)[C@H]2O3)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Shen R, et al. A novel ERα-targeted hydrophobic tag degrader, overcomes tamoxifen resistance via unfolded protein response-induced apoptosis and homologous recombination repair inhibition in breast cancer. Bioorganic chemistry. 2026 Sep 15;180:110129. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
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ERα ligand 6

All Estrogen Receptor/ERR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

ERα ligand 6 Related Classifications

HY-187621 Related Classifications