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Cat. No.: HY-18849

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ERK2-IN-3

ERK2-IN-3 (compound 2) is a inhibitor of ERK2, and inhibits Erk2^WT and Erk2^DS1 activation loop phosphorylation, with IC₅₀ of 5 μM and 42 nM, respectively.

For research use only. We do not sell to patients.

CAS No.: 1415050-57-5
Formula: C₂₆H₂₁F₃N₄O
Molecular Weight:462.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

ERK2-IN-3 Chemical Structure

CAS No.: 1415050-57-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

ERK2-IN-3 (compound 2) is a inhibitor of ERK2, and inhibits Erk2^WT and Erk2^DS1 activation loop phosphorylation, with IC₅₀ of 5 μM and 42 nM, respectively^[1].

IC₅₀ & Target

5 μM and 42 nM（Erk2^WT and Erk2^DS1 ）^[1].

All ERK Isoforms :

Chemical Information

CAS No. 1415050-57-5
Molecular Weight 462.47
Formula C₂₆H₂₁F₃N₄O
SMILES

CC1=CC=C(NC(C2=CC=CC(C(F)(F)F)=C2)=O)C=C1C3=CC=C4C(C=NC(NC5CC5)=N4)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hari SB, et al. Conformation-selective ATP-competitive inhibitors control regulatory interactions and noncatalytic functions of mitogen-activated protein kinases. Chem Biol. 2014;21(5):628-635. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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ERK2-IN-3

All ERK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

ERK2-IN-3 Related Classifications

HY-18849 Related Classifications