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Cat. No.: HY-174274

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ERK2-IN-6

ERK2-IN-6 (Compound 20) is a highly selective ERK1/2 inhibitor with an IC₅₀ value of 7.9 nM for ERK2. ERK2-IN-6 inhibits the proliferation of BRAF^V600E mutant cells (IC₅₀=250 nM in A375 cells). ERK2-IN-6 is promising for research of solid tumors, such as BRAF-mutated melanoma.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2095713-33-8
화학식: C₂₈H₃₀ClN₅O₃
분자량:520.02

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

ERK2-IN-6 Chemical Structure

CAS No.: 2095713-33-8

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

ERK1	ERK2 7.9 nM (IC₅₀)

All ERK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	250 nM Compound: 20	Antiproliferative activity against human A375 cells harboring BRAF V600E mutant after 96 hrs by Alamar blue assay Antiproliferative activity against human A375 cells harboring BRAF V600E mutant after 96 hrs by Alamar blue assay	[PMID: 29775310]
COLO 205	IC₅₀	310 nM Compound: 20	Antiproliferative activity against human COLO205 cells harboring BRAF V600E mutant after 96 hrs by Alamar blue assay Antiproliferative activity against human COLO205 cells harboring BRAF V600E mutant after 96 hrs by Alamar blue assay	[PMID: 29775310]

Chemical Information

CAS No. 2095713-33-8
분자량 520.02
화학식 C₂₈H₃₀ClN₅O₃
SMILES

O=C1C2=C(CN1CC(NC(C)(C)C3=CC=CC=C3)=O)C=CC(C4=NC(NC5CCOCC5)=NC=C4Cl)=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Heightman TD, et al. Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J Med Chem. 2018 Jun 14;61(11):4978-4992. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

ERK2-IN-6

All ERK Isoforms

Biological Activity

제품 설명

IC50 & Target

Cellular Effect

Chemical Information

순도&문서

References

Calculators

Help & FAQs

ERK2-IN-6 Related Classifications

HY-174274 Related Classifications

Bioz

Keywords

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