2. MAPK/ERK Pathway Stem Cell/Wnt
  3. ERK
  4. ERK2-IN-6

ERK2-IN-6 (Compound 20) is a highly selective ERK1/2 inhibitor with an IC50 value of 7.9 nM for ERK2. ERK2-IN-6 inhibits the proliferation of BRAFV600E mutant cells (IC50=250 nM in A375 cells). ERK2-IN-6 is promising for research of solid tumors, such as BRAF-mutated melanoma.

For research use only. We do not sell to patients.

ERK2-IN-6

ERK2-IN-6 Chemical Structure

CAS No. : 2095713-33-8

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ERK2-IN-6 Related Antibodies

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ERK ERK1 ERK2 ERK5 ERK8

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Description

ERK2-IN-6 (Compound 20) is a highly selective ERK1/2 inhibitor with an IC50 value of 7.9 nM for ERK2. ERK2-IN-6 inhibits the proliferation of BRAFV600E mutant cells (IC50=250 nM in A375 cells). ERK2-IN-6 is promising for research of solid tumors, such as BRAF-mutated melanoma[1].

IC50 & Target

ERK1

 

ERK2

7.9 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
A-375 IC50
250 nM
Compound: 20
Antiproliferative activity against human A375 cells harboring BRAF V600E mutant after 96 hrs by Alamar blue assay
Antiproliferative activity against human A375 cells harboring BRAF V600E mutant after 96 hrs by Alamar blue assay
[PMID: 29775310]
COLO 205 IC50
310 nM
Compound: 20
Antiproliferative activity against human COLO205 cells harboring BRAF V600E mutant after 96 hrs by Alamar blue assay
Antiproliferative activity against human COLO205 cells harboring BRAF V600E mutant after 96 hrs by Alamar blue assay
[PMID: 29775310]
Molecular Weight

520.02

Formula

C28H30ClN5O3
CAS No.
SMILES

O=C1C2=C(CN1CC(NC(C)(C)C3=CC=CC=C3)=O)C=CC(C4=NC(NC5CCOCC5)=NC=C4Cl)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ERK2-IN-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ERK2-IN-62095713-33-8ERKExtracellular signal regulated kinasesERK1/2solid tumorsmelanomaInhibitorinhibitorinhibit

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HY-174274
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