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Cat. No.: HY-N12151

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Chaparrinone

Chaparrinone is a quassinoid that can be isolated from the root of Eurycoma harmandiana. Chaparrinone has antimalarial and cytotoxic activities against Plasmodium falciparum and P-388 cells (IC₅₀: 0.037 and 0.34 μg/mL respectively).

For research use only. We do not sell to patients.

CAS No.: 22611-34-3
Formula: C₂₀H₂₆O₇
Molecular Weight:378.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Chaparrinone Chemical Structure

CAS No.: 22611-34-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
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Classifications
Bioz

Biological Activity

Description

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BT-549	IC₅₀	0.8 μg/mL Compound: chaparrinone	Cytotoxicity against human BT549 cells after 2 to 7 days by neutral red assay Cytotoxicity against human BT549 cells after 2 to 7 days by neutral red assay	[PMID: 8984156]
Hep 3B2	IC₅₀	2.17 μM Compound: 4	Cytotoxicity against human Hep3B cells measured after 48 hrs by MTT assay Cytotoxicity against human Hep3B cells measured after 48 hrs by MTT assay	[PMID: 23290052]
HepG2	IC₅₀	>50 μM Compound: 4	Cytotoxicity against human adriamycin-resistant HepG2 cells measured after 48 hrs by MTT assay Cytotoxicity against human adriamycin-resistant HepG2 cells measured after 48 hrs by MTT assay	[PMID: 23290052]
HepG2	IC₅₀	1.2 μM Compound: 4	Cytotoxicity against human HepG2 cells measured after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells measured after 48 hrs by MTT assay	[PMID: 23290052]
HL-60	EC₅₀	2.4 μM Compound: 26	Induction of cell differentiation in human HL60 cells assessed as superoxide anion production after 4 days by NBT reduction assay Induction of cell differentiation in human HL60 cells assessed as superoxide anion production after 4 days by NBT reduction assay	[PMID: 11754601]
HL-60	IC₅₀	1.2 μM Compound: 26	Antiproliferative activity against human HL60 cells assessed as inhibition of [3H]thymidine incorporation after 4 days by liquid scintillation counter Antiproliferative activity against human HL60 cells assessed as inhibition of [3H]thymidine incorporation after 4 days by liquid scintillation counter	[PMID: 11754601]
HL-60	IC₅₀	5 μM Compound: 26	Cytotoxicity against human HL60 cells assessed as loss of membrane integrity after 4 days by trypan blue exclusion assay Cytotoxicity against human HL60 cells assessed as loss of membrane integrity after 4 days by trypan blue exclusion assay	[PMID: 11754601]
K562	IC₅₀	1.8 μg/mL Compound: chaparrinone	Cytotoxicity against human K562 cells after 2 to 7 days by neutral red assay Cytotoxicity against human K562 cells after 2 to 7 days by neutral red assay	[PMID: 8984156]
KB	ED₅₀	0.025 μg/mL Compound: 2, NSC-288754	Cytotoxicity against human KB cells by NCI method Cytotoxicity against human KB cells by NCI method	[PMID: 6875576]
KB	IC₅₀	1.2 μg/mL Compound: chaparrinone	Cytotoxicity against human KB cells after 2 to 7 days by neutral red assay Cytotoxicity against human KB cells after 2 to 7 days by neutral red assay	[PMID: 8984156]
P388	IC₅₀	0.92 μg/mL Compound: 6	Cytotoxicity against mouse P388 cells after 3 days by MTT assay Cytotoxicity against mouse P388 cells after 3 days by MTT assay	[PMID: 9644063]
SK-OV-3	IC₅₀	0.5 μg/mL Compound: chaparrinone	Cytotoxicity against human SKOV3 cells after 2 to 7 days by neutral red assay Cytotoxicity against human SKOV3 cells after 2 to 7 days by neutral red assay	[PMID: 8984156]
Vero	IC₅₀	1.5 μg/mL Compound: chaparrinone	Cytotoxicity against african green monkey Vero cells after 2 to 7 days by neutral red assay Cytotoxicity against african green monkey Vero cells after 2 to 7 days by neutral red assay	[PMID: 8984156]

Chemical Information

CAS No. 22611-34-3
Molecular Weight 378.42
Formula C₂₀H₂₆O₇
SMILES

C[C@@]12[C@]3([H])[C@@]45[C@@](OC(C[C@@]4([H])[C@H]([C@H]([C@@]3(OC5)O)O)C)=O)([H])C[C@@]1([H])C(C)=CC([C@H]2O)=O
Structure Classification
- Others
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kanchanapoom T, et al. Quassinoids from Eurycoma harmandiana. Phytochemistry. 2001 Aug;57(8):1205-8. [Content Brief]

[2]. François G, et al. Antimalarial and cytotoxic potential of four quassinoids from Hannoa chlorantha and Hannoa klaineana, and their structure-activity relationships. Int J Parasitol. 1998 Apr;28(4):635-40. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Chaparrinone

All Parasite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Chaparrinone Related Classifications

HY-N12151 Related Classifications