CXCR2 - C-X-C motif chemokine receptor 2 Gene

Also Known as CD182; IL8R2; IL8RA; IL8RB; CMKAR2; WHIMS2; CDw128b

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3579

About CXCR2

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,125,294-218,137,251 (from NCBI)

This gene has 7 transcripts (splice variants), 243 orthologues, 23 paralogues and is associated with 2 phenotypes. Biased expression in appendix (RPKM 20.0), spleen (RPKM 13.2) and 7 other tissues.

Summary

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]

CXCR2 Products (9)

mRNA	Protein	Name
XM_005246530.4	XP_005246587.1	C-X-C chemokine receptor type 2 isoform X1
XM_047444188.1	XP_047300144.1	C-X-C chemokine receptor type 2 isoform X1
XM_047444191.1	XP_047300147.1	C-X-C chemokine receptor type 2 isoform X2
XM_017003991.2	XP_016859480.1	C-X-C chemokine receptor type 2 isoform X1
NM_001557.4	NP_001548.1	C-X-C chemokine receptor type 2
XM_047444187.1	XP_047300143.1	C-X-C chemokine receptor type 2 isoform X1
XM_047444190.1	XP_047300146.1	C-X-C chemokine receptor type 2 isoform X1
NM_001168298.2	NP_001161770.1	C-X-C chemokine receptor type 2
XM_047444189.1	XP_047300145.1	C-X-C chemokine receptor type 2 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables C-X-C chemokine receptor activity	IDA IDA: Inferred from direct assay	10878382	GOA
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	10438939	GOA
enables interleukin-8 binding	IPI IPI: Inferred from physical interaction	1840701	GOA
enables interleukin-8 receptor activity	IDA IDA: Inferred from direct assay	10820279	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17435771	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	10734056	GOA
involved in cellular defense response	IDA IDA: Inferred from direct assay	10725748	GOA
involved in chemotaxis	IDA IDA: Inferred from direct assay	10725748	GOA
involved in interleukin-8-mediated signaling pathway	IDA IDA: Inferred from direct assay	10820279	GOA
involved in neutrophil activation	IDA IDA: Inferred from direct assay	10878382	GOA
involved in neutrophil chemotaxis	IDA IDA: Inferred from direct assay	10820279	GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	10438939	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	10438939	GOA
involved in receptor internalization	IDA IDA: Inferred from direct assay	10734056	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	10878382	GOA
located in mast cell granule	IDA IDA: Inferred from direct assay	9725262	GOA
located in membrane	IDA IDA: Inferred from direct assay	10725748	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CXCR2 Protein Structure

7tm_1

0
100
200
300
360 a.a.

Protein Preferred Names	Protein Names
C-X-C chemokine receptor type 2	CXC-R2 CXCR-2 CXCR2 gene for IL8 receptor type B GRO/MGSA receptor IL-8 receptor type 2 IL-8R B chemokine (CXC) receptor 2 high affinity interleukin-8 receptor B interleukin 8 receptor type 2 interleukin 8 receptor, beta interleukin-8 receptor type B

CXCR2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CXCR2	P25025	TMEM80	Homo sapiens	Q96HE8	Validated Y2H	32296183
Intra	CXCR2	P25025	TMEM80	Homo sapiens	Q96HE8	Y2H Array	32296183
Intra	CXCR2	P25025	TMEM80	Homo sapiens	Q96HE8	Y2H Prey Pooling	32296183
Intra	CXCR2	P25025	C4orf3	Homo sapiens	Q8WVX3-2	Validated Y2H	32296183
Intra	CXCR2	P25025	ATP13A1	Homo sapiens	Q9HD20-3	Validated Y2H	32296183
Intra	CXCR2	P25025	SLC39A2	Homo sapiens	Q9NP94	Y2H Array	32296183
Intra	CXCR2	P25025	SLC39A2	Homo sapiens	Q9NP94	Y2H Prey Pooling	32296183
Intra	CXCR2	P25025	SLC39A2	Homo sapiens	Q9NP94	Validated Y2H	32296183
Intra	CXCR2	P25025	CLDN22	Homo sapiens	Q8N7P3	Validated Y2H	32296183
Intra	CXCR2	P25025	SLC18A2	Homo sapiens	Q05940	Validated Y2H	32296183
Intra	CXCR2	P25025	SLC18A2	Homo sapiens	Q05940	Y2H Array	32296183
Intra	CXCR2	P25025	SLC18A2	Homo sapiens	Q05940	Y2H Prey Pooling	32296183
Intra	CXCR2	P25025	IQGAP1	Homo sapiens	P46940	Crosslink	21876773
Intra	CXCR2	P25025	IQGAP1	Homo sapiens	P46940	Confocal	21876773
Intra	CXCR2	P25025	IQGAP1	Homo sapiens	P46940	Anti Bait CoIP	21876773
Intra	CXCR2	P25025	IQGAP1	Homo sapiens	P46940	Pull Down	21876773
Intra	CXCR2	P25025	TMEM147	Homo sapiens	Q9BVK8	Validated Y2H	32296183
Intra	CXCR2	P25025	CXCL8	Homo sapiens	P10145	SPR	22904195
Intra	CXCR2	P25025	CXCL8	Homo sapiens	P10145	SPA	23597562
Intra	CXCR2	P25025	EMP1	Homo sapiens	P54849	Validated Y2H	32296183
Intra	CXCR2	P25025	GPR17	Homo sapiens	Q13304-2	Anti Bait CoIP	36613703
Intra	CXCR2	P25025	FKBP8	Homo sapiens	Q14318	Validated Y2H	32296183
Intra	CXCR2	P25025	SMCO4	Homo sapiens	Q9NRQ5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CXCR2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700536	CXCR2 Protein, Human (His-SUMO)	P25025 (M1-E40)	≥ 90%, as determined by reducing SDS-PAGE.

CXCR2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81158	CXCR2 Antibody	WB, IHC-P, ELISA	Human
HY-P84207	CXCR2 Antibody (YA3904)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P84207A	CXCR2 Antibody (YA3904)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Whim Syndrome 1	Whim Syndrome Whims Warts, Hypogammaglobulinemia, Infections, And Myelokathexis WHIMS1 Warts-Hypogammaglobulinemia-Infections-Myelokathexis Syndrome Warts, Hypogammaglobulinemia, Infections, And Myelokathexis Syndrome 1 Myelokathexis, Isolated Wilm Warts-Infections-Leukopenia-Myelokatexis Syndrome Warts, Hypogammaglobulinemia, Infections And Myelokathexis Syndrome 1
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Bacteriuria
Lymphopenia	Lymphocytopenia
Whim Syndrome 2	WHIMS2 Warts, Hypogammaglobulinemia, Infections, And Myelokathexis Syndrome 2 Warts, Hypogammaglobulinemia, Infections, And Myelokathexis 2
Lung Disease	Lung Diseases Disorder Of Lung Abnormality Of The Lung
Mycetoma	Madura Foot Mycetoma Of Foot
Neutropenia	Leukopenia
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Gastric Cancer	Stomach Cancer Stomach Carcinoma Gastric Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Disease Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Cryptogenic Fibrosing Alveolitis Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Pyelonephritis
Severe Congenital Neutropenia	Congenital Neutropenia Neutropenia, Severe Congenital Congenital Agranulocytosis Infantile Genetic Agranulocytosis Kostmann Disease Kostmann'S Agranulocytosis Kostmann'S Syndrome Severe Infantile Genetic Neutropenia
Pneumonia	Acute Pneumonia Pneumonias Infectious Pneumonia Pn - [Pneumonia] Lobar Pneumonia Nos Multifocal Pneumonia Orthostatic Pneumonia Pneumonia Nos Chronic Pneumonia Nos Atypical Pneumonia Passive Pneumonia Purulent Pneumonia Interstitial Lobar Pneumonia Pneumonia, Unspecified Pneumonia Due To Chlamydia Pneumonia Due To Chlamydia Pneumoniae Pneumonia Due To E. Coli Escherichia Coli Lobar Pneumonia Pneumonia Due To H. Influenzae Pneumonia Due To Hemophilus Influenzae Bronchopneumonia Due To H. Influenzae Haemophilus Influenzae Lobar Pneumonia Bronchopneumonia Due To Hemophilus Influenzae Pseudomonal Pneumonia Pseudomonas Pneumonia Pseudomonas Lobar Pneumonia Staphylococcal Pneumonia Staphylococcus Pneumonia Acute Staphylococcal Pneumonia Staphylococcal Double Pneumonia Staphylococcal Lobar Pneumonia Staphylococcal Purulent Pneumonia Staphylococcal Bronchopneumonia Pneumococcal Pneumonia Pneumococcus Pneumonia Bronchopneumonia Due To S. Pneumoniae Pneumococcal Lobar Pneumonia Streptococcal Pneumoniae Pneumonia Streptococcus Pneumoniae Lobar Pneumonia Pyemic Pneumococcal Embolism With Pneumonia Bronchopneumonia Due To Streptococcus Pneumoniae Pneumonia Due To Streptococcus, Group B Group B Streptococcal Pneumonia Adenovirus Pneumonia Adenoviral Pneumonia Adenovirus Viral Pneumonia Pneumonia Respiratory Syncytial Viral Parainfluenza Viral Pneumonia Parainfluenzal Pneumonia Parainfluenza Virus Pneumonia Human Metapneumovirus Pneumonia Human Metapneumovirus Infection Resulting In Pneumonia Pneumocystis Pneumonia Plasma Cells Pneumonia
Pulmonary Disease, Chronic Obstructive	Chronic Obstructive Pulmonary Disease COPD Pulmonary Disease, Chronic Obstructive, Severe Early-Onset Chronic Obstructive Lung Disease Chronic Obstructive Airway Disease Pulmonary Disease, Chronic Obstructive, Susceptibility To Cold Severe Early-Onset Chronic Obstructive Pulmonary Disease Pulmonary Disease Chronic Obstructive Pulmonary Disease, Obstructive, Chronic, Susceptibility To Chronic Obstructive Pulmonary Disease Of Horses Common Cold Upper Respiratory Infections Copd - [Chronic Obstructive Pulmonary Disease] Coad - [Chronic Obstructive Airways Disease] Cold - [Chronic Obstructive Lung Disease] Chronic Airway Disease Nos Chronic Airways Limitation, Unspecified Chronic Obstructed Airway, Unspecified Chronic Obstructive Airway Disease, Unspecified Chronic Obstructive Airway, Unspecified Obstructive Lung Disease Nos Chronic Obstructive Lung Disease Nos Chronic Obstructive Lung Nos Obstructive Pulmonary Disease Nos Exacerbation Copd Nos Acute Exacerbation Copd
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Autosomal Recessive Severe Congenital Neutropenia Due To Cxcr2 Deficiency
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Spermatogenic Failure 24	SPGF24 Spermatogenic Failure, Type 24
Leukocyte Adhesion Deficiency, Type I	Leukocyte Adhesion Deficiency Leukocyte Adhesion Deficiency 1 LAD1 Lad Leukocyte Adhesion Deficiency Type 1 Lymphocyte Function-Associated Antigen 1 Immunodeficiency Leukocyte Adhesion Deficiency Type I Linear Iga Bullous Dermatosis Linear Iga Dermatosis Leukocyte-Adhesion Deficiency Syndrome Lfa1 Immunodeficiency Congenital Leukocyte Adherence Deficiency Lad-I Linear Iga Disease Leukocyte Adhesion Deficiency Syndrome Lad 1 Lfa 1 Immunodeficiency Linear Immunoglobulin A Dermatosis Leucocyte Adhesion Deficiency Type 1 Leukocyte Adhesion Molecule Deficiency Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15251	Reparixin	Inhibitor	99.99%	Phase 3
HY-19519A	Ladarixin sodium	Antagonist	99.84%	Phase 3
HY-10198	Navarixin	Antagonist	99.33%	Phase 2
HY-13848	Rugocrixan		99.54%	Phase 2
HY-19855	AZD-5069	Antagonist	99.91%	Phase 2
HY-119339	SX-682	Inhibitor	99.64%	Phase 2
HY-50688	SB-265610	Antagonist	99.03%	Phase 2
HY-19768	Danirixin	Antagonist	98.19%	Phase 2
HY-15462	SRT3109	Antagonist	99.68%	Phase 1

Pre-clinical Phase

Bioactive Molecules (28)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16711	SB225002	Antagonist	99.90%	Unkown
HY-15252	Reparixin L-lysine salt	Inhibitor	99.87%	Yes
HY-120427	Cosalane	Antagonist	99.78%	Unkown
HY-101407	Nicotinamide N-oxide	Antagonist	99.85%	Unkown
HY-121983	CAY10594	Modulator	98.64%	Unkown
HY-P4846	Ac-Pro-Gly-Pro-OH	Agonist	99.49%	Unkown
HY-12927	SX-517	Antagonist	99.90%	Unkown
HY-18263C	Elubrixin tosylate	Antagonist	98.14%	Unkown
HY-10011	SCH 563705	Antagonist	99.86%	Unkown
HY-101022	CXCR2-IN-1	Inhibitor	99.54%	Unkown
HY-165428	SCH-900875	Inhibitor	98.16%	Unkown
HY-120878	CXCR2-IN-2	Antagonist	99.52%	Unkown
HY-119259	AZD8309	Antagonist	99.98%	Unkown
HY-147392	CXCR2 antagonist 8	Antagonist	98.38%	Unkown
HY-181654	Snail IN-1	Inhibitor	98.27%	Unkown
HY-18263A	Elubrixin	Antagonist	/	Unkown
HY-13021	SRT3190	Antagonist	99.77%	Unkown
HY-101407R	Nicotinamide N-oxide (Standard)	Antagonist	99.03%	Unkown
HY-181681	CXCR2 antagonist 10	Antagonist	/	Unkown
HY-179387	CXCR2-IN-3	Inhibitor	/	Unkown
HY-110268	NVP CXCR2 20	Antagonist	/	Unkown
HY-144784	CXCR2 antagonist 7	Antagonist	/	Unkown
HY-144780	CXCR2 antagonist 4	Antagonist	/	Unkown
HY-124056	AZ10397767	Antagonist	/	Unkown
HY-144781	CXCR2 antagonist 5	Antagonist	/	Unkown
HY-117823	VUF11418	Agonist	/	Unkown
HY-144783	CXCR2 antagonist 6	Antagonist	/	Unkown
HY-N2573	Corydalmine	Inhibitor	99.74%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CXCR2	VGNC	VGNC:84225
Mus musculus	CXCR2	MGD	MGI:105303
Rattus norvegicus	CXCR2	RGD	RGD:2906
Others	CXCR2	NCBI