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Cat. No.: HY-149462

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KN1022

KN1022 an inhibitor of phosphorylation of platelet-derived growth factor receptor (PDGFR) with IC₅₀ of 0.24 μM.

For research use only. We do not sell to patients.

CAS No.: 205255-11-4
Formula: C₂₁H₂₂N₆O₅
Molecular Weight:438.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

KN1022 Chemical Structure

CAS No.: 205255-11-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
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Biological Activity

Description

KN1022 an inhibitor of phosphorylation of platelet-derived growth factor receptor (PDGFR) with IC₅₀ of 0.24 μM^[1].

All PDGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.7 μM Compound: KN1022	Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells	[PMID: 12941321]
CHO	IC₅₀	0.7 μM/L Compound: KN1022	Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cells	[PMID: 12941321]
PASMC	IC₅₀	0.1 μM Compound: KN1022	Inhibition of PDGF-BB-induced proliferation of porcine aorta smooth muscle cells Inhibition of PDGF-BB-induced proliferation of porcine aorta smooth muscle cells	[PMID: 12086491]
PASMC	IC₅₀	0.1 μM/L Compound: KN1022	Inhibition of PDGF-BB-induced proliferation of porcine aorta smooth muscle cells Inhibition of PDGF-BB-induced proliferation of porcine aorta smooth muscle cells	[PMID: 12086491]

Chemical Information

CAS No. 205255-11-4
Molecular Weight 438.44
Formula C₂₁H₂₂N₆O₅
SMILES

O=C(N1CCN(CC1)C2=C3C=C(OC)C(OC)=CC3=NC=N2)NC4=CC=C([N+]([O-])=O)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kenji Matsuno, et al. Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. 1. Synthesis, structure-activity relationship, and biological effects of a new class of quinazoline derivatives. J Med Chem. 2002 Jul 4;45(14):3057-66. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Chemical Information
Purity & Documentation
References

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KN1022

High-Throughput Bioactive Compound Library

All PDGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

KN1022 Related Classifications

HY-149462 Related Classifications