Saccharolactone
Based on 1 publication(s) in Google Scholar
Saccharolactone is a potent orally active β-glucuronidase inhibitor. Saccharolactone markedly lowers biliary endogenous β-glucuronidase activity in the rat bile. Saccharolactone can stabilize glucuronide metabolites in vitro. Saccharolactone is also a strong inhibitor of CYP1A2, 2D6, 3A4 and 2C8 isoforms (IC50 < 4 mM).
For research use only. We do not sell to patients.
- CAS No.: 389-36-6
- Formula: C6H8O7
- Molecular Weight:192.12
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Saccharolactone
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Biological Activity
Description
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CYP1A2 <4 mM (IC50) |
CYP2D6 <4 mM (IC50) |
CYP3A4 <4 mM (IC50) |
CYP2C8 <4 mM (IC50) |
Chemical Information
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CAS No. 389-36-6
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Molecular Weight 192.12
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Formula C6H8O7
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SMILES
OC([C@H]([C@]1([H])[C@@H]([C@H](C(O1)=O)O)O)O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Enzyme Inhib Med Chem
Design, synthesis, and biological evaluation of (thio)urea derivatives as potent Escherichia coli β-glucuronidase inhibitors. [Abstract]2024 Dec;39(1):2387415. PMID: 39140677
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Macfadyen A, et al. D-glucaro-1,4-lactone: its excretion in the bile and urine and effect on the biliary secretion of beta-glucuronidase after oral administration in rats. Hepatology. 1989 Apr;9(4):552-6. [Content Brief]
[2]. Behera D, et al. Effect of Saccharolactone on CYP-mediated Metabolism of Xenobiotics. Drug Metab Bioanal Lett. 2023;16(2):121-132. [Content Brief]
[3]. Oleson L, et al. Effect of the beta-glucuronidase inhibitor saccharolactone on glucuronidation by human tissue microsomes and recombinant UDP-glucuronosyltransferases. J Pharm Pharmacol. 2008 Sep;60(9):1175-82. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Saccharolactone Related Classifications
HY-153875 Related Classifications
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