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Amivantamab

(Synonyms: JNJ-61186372)
3 Cited Publications
Revisión del cliente

Based on 3 publication(s) in Google Scholar

Amivantamab (JNJ-61186372) is a human EGFR-MET bispecific antibody with immune anticancer activity. Amivantamab inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes, and induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells.

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  • Pureza: 99.90%
  • No. CAS: 2171511-58-1
  • Peso molecular:145.88 kDa
  • Almacenamiento:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Amivantamab
  • Experimental Validation Results for Amivantamab
  • Experimental Validation Results for Amivantamab
  • Experimental Validation Results for Amivantamab
  • Amivantamab Chemical Structure
    Amivantamab Chemical Structure
No. CAS: 2171511-58-1
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[email protected] [email protected]
Encuentre su distribuidor local Your local distributor: Hycultec GmbHHycultec
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Cell Proliferation/Viability Assay
  • Cell Proliferation/Viability Assay

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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized Human c-MET/HGFR Protein (ECD, His Tag) can bind Amivantamab. The EC50 for this effect is 1.20 ng/mL.

  • 1/16

    Immobilized Human EGFR Protein can bind Amivantamab. The EC50 for this effect is 2.58 ng/mL.

  • 1/16

    Amivantamab purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2023 Nov 4;42(1):292. [Abstract]

    Customer Validation
     (A) MDA-MB-231 and (B) BT549 cells were treated with various concentrations of Amivantamab (1–1000 μg/ml) or control vehicle (DMSO) for 72 h.

  • Amivantamab Chemical Structure
    1/16
  • Amivantamab
  • Immobilized Human c-MET/HGFR Protein (ECD, His Tag) can bind Amivantamab. The EC50 for this effect is 1.20 ng/mL.
  • Immobilized Human EGFR Protein can bind Amivantamab. The EC50 for this effect is 2.58 ng/mL.