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United States

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Referencia número: HY-P992511

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CS2009

CS2009 is a trispecific antibody targeting PD-1, CTLA-4 and VEGFA. CS2009 blocks the interactions of PD-1/PD-L1, CTLA-4/CD80 and VEGFA/VEGFR2, mediates checkpoint inhibition, and suppresses tumor angiogenesis. CS2009 reactivates PD-1/CTLA-4 double-positive tumor-infiltrating T lymphocytes, induces T cell activation, enhances tumor growth inhibition, promotes vascular normalization, improves T lymphocyte infiltration, and converts the immunosuppressive tumor microenvironment into an immunocompetent one. CS2009 can be used for the research of various advanced solid tumors.

Para uso exclusivo en investigación. No vendemos a pacientes.

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

CS2009 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Species Reactivity
- In Vitro
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Aplicación
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Species Reactivity

Human

Ver todos los productos específicos de isoformas VEGFR :

In Vitro

CS2009 preferentially targets and activates PD-1/CTLA-4 double-positive tumor-infiltrating T lymphocytes (TILs); its anti-VEGFA arm inhibits tumor angiogenesis and promotes vascular normalization, which helps convert the immunosuppressive tumor microenvironment (TME) into an immunocompetent TME, thereby enhancing effector TIL-mediated tumor growth inhibition^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gene ID

29126 [NCBI] & 7422 [NCBI] & 1493 [NCBI]

Accession

Q9NZQ7 & P15692 & P16410

Target

PD-1 & VEGF & CTLA-4

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

Aplicación

ELISA, FACS, Functional assay

Chemical Information

Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Inhibitory Antibodies User Guide (603 KB)

Referencias

[1]. Wang C, et al. CS2009: A first-in-class trispecific antibody targeting PD-1, CTLA-4, and VEGFA with potential to be a next-generation backbone therapy with combined checkpoint inhibition and anti-angiogenesis. Cancer Research. 2025 Apr 21;85(8_Supplement_1):7299-.

[2]. Wang C, et al. 504 CS2009, a novel first-in-class trispecific antibody targeting PD-1, CTLA-4, and VEGFa, demonstrates promising anti-tumor activity in preclinical evaluation.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Actividad biológica
- Descripciòn
- Species Reactivity
- In Vitro
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Aplicación
Chemical Information
Pureza y Documentación
Referencias

Nombre del producto:
Referencia número:
Cantidad:
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Cantidad:

CS2009

Cytotoxicity LDH Assay Kit

DPBS Buffer (1×)

PBS Buffer (1×)

Ver todos los productos específicos de isoformas VEGFR