country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-122115

Copy Link Print Information

DCE_42

DCE_42 is a potent EZH2 inhibitor with an IC₅₀ value of 22.6 µM. DCE_42 inhibits cell proliferation and has the potential for the research of lymphoma.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 669749-45-5
Fòrmula: C₂₂H₁₉N₉O₂S
Peso molecular:473.51

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

DCE_42 Chemical Structure

No. CAS: 669749-45-5

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

DCE_42 is a potent EZH2 inhibitor with an IC₅₀ value of 22.6 µM. DCE_42 inhibits cell proliferation and has the potential for the research of lymphoma^[1].

IC₅₀ & Target^[1]

EZH2

22.6 μM (IC₅₀)

Ver todos los productos específicos de isoformas Histone Methyltransferase :

Cellular Effect

Cell Line	Type	Value	Description	References
DB	IC₅₀	32.8 μM Compound: DCE_42	Antiproliferative activity against human DB cells expressing EZH2 mutant assessed as growth inhibition measured after 72 hrs by AlamaBlue assay Antiproliferative activity against human DB cells expressing EZH2 mutant assessed as growth inhibition measured after 72 hrs by AlamaBlue assay	[PMID: 27289323]
Toledo	IC₅₀	24.1 μM Compound: DCE_42	Antiproliferative activity against human Toledo cells expressing wild-type EZH2 assessed as growth inhibition measured after 72 hrs by AlamaBlue assay Antiproliferative activity against human Toledo cells expressing wild-type EZH2 assessed as growth inhibition measured after 72 hrs by AlamaBlue assay	[PMID: 27289323]

In Vitro

DCE_42 inhibits Toledo and DB cell proliferation with IC₅₀ values of 24.1, 32.8 µM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 669749-45-5
Peso molecular 473.51
Fòrmula C₂₂H₁₉N₉O₂S
SMILES

O=C1NC(NC2=NC(C)=C3C=C(C=CC3=N2)OC)=NC(CSC4=NN=NN4C5=CC=CC=C5)=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Wu Y, et al. Identification of novel EZH2 inhibitors through pharmacophore-based virtual screening and biological assays. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3813-7. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto

Amount: USD 0.00

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias

Nombre del producto:
Referencia número:
Cantidad:
MCE Japan Authorized Agent:

Nombre del producto:
No. CAS:
Species:
Pureza:
Cantidad:

DCE_42

Ver todos los productos específicos de isoformas Histone Methyltransferase