ISS610
ISS610 is a selective Stat3 inhibitor with an IC50 of 42 μM. ISS610 induces Apoptosis. ISS610 can be used in research related to breast cancer and non-small cell lung cancer.
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- No. CAS: 725233-55-6
- Fòrmula: C23H26N3O8P
- Peso molecular:503.44
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
[2]|
STAT3 42 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NIH3T3 | IC50 |
42 μM
Compound: 3, ISS610
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Inhibition of STAT3 dimerization in v-Src transformed mouse NIH/3T3 cells overexpressing human EGFR assessed as suppression of STAT3-DNA interaction in nucleus after 30 mins by EMSA
Inhibition of STAT3 dimerization in v-Src transformed mouse NIH/3T3 cells overexpressing human EGFR assessed as suppression of STAT3-DNA interaction in nucleus after 30 mins by EMSA
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[PMID: 22650325] |
In Vitro
ISS610 potently and selectively disrupts the binding of STAT3:STAT3 dimers to DNA in cell-free EMSA assays, with an IC50 of 42 μM, and exhibits low activity against STAT1:STAT1 and STAT5:STAT5 dimers[2].
ISS610 inhibits constitutive STAT3 activity and induces cell growth inhibition and apoptosis in Src-transformed mouse fibroblasts, breast cancer and non-small cell lung cancer cell lines with persistently activated STAT3, whereas its non-phosphorylated counterpart exerts no such effects[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 725233-55-6
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Peso molecular 503.44
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Fòrmula C23H26N3O8P
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SMILES
O=P(O)(O)OC(C=C1)=CC=C1C[C@@H](C(N[C@H](C(O)=O)CC(C)C)=O)NC(C2=CC=C(C=C2)C#N)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ISS610 Related Classifications
HY-113810 Related Classifications
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