SAM-315
SAM-315 (WAY-255315) is a potent antagonist of 5-Hydroxytryptamine-6, with Ki and IC50 of 1.1 nM and 4.6 nM, respectively. SAM-315 significantly increases acetylcholine and glutamate release in hippocampus of the brain.
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- No. CAS: 744218-85-7
- Fòrmula: C21H20N4O2S
- Peso molecular:392.47
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Ver todos los productos específicos de isoformas 5-HT Receptor
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Actividad biológica
Descripciòn
IC50 & Target
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5-HT6 Receptor 4.6 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
13 nM
Compound: 8at
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Antagonist activity at human cloned 5HT6 receptor expressed in human HeLa cells by cyclase assay
Antagonist activity at human cloned 5HT6 receptor expressed in human HeLa cells by cyclase assay
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[PMID: 20932009] |
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 744218-85-7
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Peso molecular 392.47
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Fòrmula C21H20N4O2S
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SMILES
O=S(C1=NNC2=C1C=C(N3CCNCC3)C=C2)(C4=CC=CC5=C4C=CC=C5)=O
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Synonyms
WAY-255315
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SAM-315 Related Classifications
HY-14334 Related Classifications
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