SWTX-143
Based on 1 Customer Validation
SWTX-143 is an orally active YAP/TAZ-TEAD inhibitor that binds to the palmitoylation pocket of all four TEAD isoforms. SWTX-143 causes irreversible and specific inhibition of the transcriptional activity of YAP/TAZ-TEAD and shows antitumor activity.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.29%
- No. CAS: 2766575-48-6
- Fòrmula: C19H18F3N3O
- Peso molecular:361.36
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Chemical Information
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Solvente y solubilidad
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Ver todos los productos específicos de isoformas YAP
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Actividad biológica
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YAP/TAZ-TEAD |
SWTX-143 (5-207 nM, 6 days) inhibits the proliferation of NF2-deficient mesothelioma cells, with IC50 values ranging from 5 to 207 nM[1].
SWTX-143 (12 nM, 24 hours) selectively inhibits TEAD transcription factor activity in HEK293 cells, with an IC50 of 12 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NCI-H226, NCI-H2052, Mero-14 (NF2-deficient mesothelioma cell lines)
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Concentration:5 to 207 nM
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Incubation Time:6 days
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Result:Inhibited proliferation in NF2-deficient mesothelioma cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NF2-deficient human mesothelioma (NCI-H226) xenograft BALB/c nude mice model
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Dosage:10, 25, and 50 mg/kg
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Administration:Oral gavage (p.o.), once daily for 19 days
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Result:Had little effect on tumor volume during the first week of dosing; Resulted in significant dose-dependent reduction in tumor volume observed afterward; Led to no significant weight loss at the end of dosing.
Chemical Information
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No. CAS 2766575-48-6
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Appearance Solid
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Peso molecular 361.36
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Fòrmula C19H18F3N3O
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Color White to off-white
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SMILES
O=C(C=C)NC1CC2=C(N)C=CC=C2N(C3=CC=C(C(F)(F)F)C=C3)C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 125 mg/mL (345.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7673 mL | 13.8366 mL | 27.6732 mL | 69.1831 mL |
| 5 mM | 0.5535 mL | 2.7673 mL | 5.5346 mL | 13.8366 mL | |
| 10 mM | 0.2767 mL | 1.3837 mL | 2.7673 mL | 6.9183 mL | |
| 15 mM | 0.1845 mL | 0.9224 mL | 1.8449 mL | 4.6122 mL | |
| 20 mM | 0.1384 mL | 0.6918 mL | 1.3837 mL | 3.4592 mL | |
| 25 mM | 0.1107 mL | 0.5535 mL | 1.1069 mL | 2.7673 mL | |
| 30 mM | 0.0922 mL | 0.4612 mL | 0.9224 mL | 2.3061 mL | |
| 40 mM | 0.0692 mL | 0.3459 mL | 0.6918 mL | 1.7296 mL | |
| 50 mM | 0.0553 mL | 0.2767 mL | 0.5535 mL | 1.3837 mL | |
| 60 mM | 0.0461 mL | 0.2306 mL | 0.4612 mL | 1.1531 mL | |
| 80 mM | 0.0346 mL | 0.1730 mL | 0.3459 mL | 0.8648 mL | |
| 100 mM | 0.0277 mL | 0.1384 mL | 0.2767 mL | 0.6918 mL |
SWTX-143 Related Classifications
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