1. GPCR/G Protein Neuronal Signaling
  2. mAChR
  3. Ethybenztropine

Ethybenztropine  (Synonyms: Ponalid; UK 738)

Cat. No.: HY-118406
Handling Instructions

Ethybenztropine (Ponalid) is a muscarinic receptor blocker. Ethybenztropine is an anticholinergic and antihistaminergic agent.

For research use only. We do not sell to patients.

Ethybenztropine Chemical Structure

Ethybenztropine Chemical Structure

CAS No. : 524-83-4

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Description

Ethybenztropine (Ponalid) is a muscarinic receptor blocker. Ethybenztropine is an anticholinergic and antihistaminergic agent[1].

IC50 & Target

Muscarinic Receptor[1]

In Vitro

Ethybenztropine (10 μM) inhibits the uptake of 3H-DA in neostriatal slices.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ethybenztropine (25 μg, microinjected into mesencephalic NRM) blocks the hypertherrnic response of carbachol microinjection into nucleus raphe median (NRM) of rabbits[1].
Ethybenztropine (30-60 μg/kg, administered by the fourth ventricle) is effective in preventing arrhythmias in dogs[2].
Ethybenztropine (50 mg/kg, i.p.) reduces the catecholamines accumulation in rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Dogs with cardiac arrhythmias[2]
Dosage: 30-60 μg/kg
Administration: Administered by the fourth ventricle
Result: Produced slight hypotension (never exceeding a fall of 25 mm Hg) and slight sinus tachycardia.
Converted arrhythmias to sinus rhythms.
Molecular Weight

321.46

Formula

C22H27NO

CAS No.
SMILES

CCN([C@@H](CC1)C2)[C@H]1C[C@@H]2OC(C3=CC=CC=C3)C4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Ethybenztropine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Ethybenztropine
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HY-118406
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